Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine.
Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine.
复制标题
黄酮类水飞蓟素对苯肼引起的红细胞溶血的抑制作用。
DOI：
10.1016/0006-291x(85)90243-8
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
A. Garrido
中科院分区：
文献类型：
--
作者：
A. Valenzuela;Teresa Barría;R. Guerra;A. Garrido
水飞蓟素类黄酮可抑制苯肼对大鼠红细胞的溶血和脂质过氧化作用，是一种治疗肝脏疾病的药物。这种作用归因于黄酮类化合物所表现出的自由基清除剂的抗氧化特性。水飞蓟素对苯肼引起的红细胞谷胱甘肽耗竭无抑制作用。提出类黄酮在细胞的膜水平起作用，避免苯肼的脂质过氧化和流化作用。
The flavonoid silymarin, which is used as a therapeutical agent in the treatment of liver diseases, can inhibit the hemolysis and lipid peroxidation induced by phenylhydrazine on erythrocytes obtained from rats treated with the flavonoid. This effect is ascribed to the antioxidant properties as a free radical scavenger exhibited by the flavonoid. Silymarin failed to inhibit the glutathione depletion induced by phenylhydrazine on erythrocytes. It is proposed that the flavonoid acts at the membrane level of the cell avoiding the lipid peroxidative and fluidizing effect of phenylhydrazine.