Prediction of electrophoretic mobilities in non-aqueous capillary electrophoresis -: Optimal separation of quinolones in acetonitrile-water media
Prediction of electrophoretic mobilities in non-aqueous capillary electrophoresis -: Optimal separation of quinolones in acetonitrile-water media
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DOI：
10.1016/s0021-9673(99)00858-4
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发表时间：
2000-02-25
影响因子：
4.1
通讯作者：
Barbosa, J
中科院分区：
文献类型：
--
作者：
Barrón, D;Irles, A;Barbosa, J
一个模型的电泳行为是用来预测的最佳条件下分离的一系列喹诺酮类两性离子物质的混合物中的乙腈-水高达30%（w/w）的乙腈。pH值，pK（a），质子化和阴离子物种的电泳迁移率，和活动系数上的喹诺酮类的电泳行为的影响被认为是。提出的模型允许乙腈-水混合物中的物质之间的分辨率从几个实验数据进行预测，从而允许一个获得最佳的实验条件分离方法。(C)2000 Elsevier Science B. V.保留所有权利。
A model of electrophoretic behaviour is used to predict the optimum conditions for the separation of a series of quinolones zwitterionic substances in mixtures of acetonitrile-water up to 30% (w/w) of acetonitrile. The effect of pH, pK(a), the electrophoretic mobility of protonated and anionic species, and activity coefficients on the electrophoretic behaviour of quinolones is considered. The model proposed allows the resolution between substances in acetonitrile-water mixtures to be predicted from a few experimental data and thus permits one to obtain the best experimental conditions for separation methodologies. (C) 2000 Elsevier Science B.V. All rights reserved.