Age-associated modulations of cerebral oscillatory patterns related to attention control
Age-associated modulations of cerebral oscillatory patterns related to attention control
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DOI：
10.1016/j.neuroimage.2013.06.037
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发表时间：
2013-11-15
期刊：
影响因子：
5.7
通讯作者：
Giannakopoulos, Panteleimon
中科院分区：
文献类型：
--
作者：
Deiber, Marie-Pierre;Ibanez, Vicente;Giannakopoulos, Panteleimon
视觉注意依赖于自下而上的感觉激活和自上而下的注意引导。虽然已知衰老会影响感官处理，但它对自上而下的注意力控制的影响仍然是一个有争议的问题。我们调查了年龄相关的调制过程中的视觉注意的注意力网络测试（ANT）在20名年轻人和28名老年人的大脑振荡活动。我们研究了EEG对警告和目标信号的振荡反应，并探讨了时间和空间定向以及目标呈现时的冲突解决的相关性。在4 ~ 30 Hz频率范围内进行时频分析，分析行为反应与脑振荡反应之间的关系。而时间线索和冲突在两个年龄组有类似的反应时间的影响，空间线索是更有益的老年人比年轻的受试者。在没有提示的情况下，老年人的后α激活急剧减少，这表明预期注意力与年龄有关。在线索和目标之后，老年人在低β频率范围内表现出明显的运动相关激活，而在年轻人中与注意力相关的后部α激活则很突出。这些研究结果支持招聘的替代运动相关的电路在老年人中，与去分化假说。此外，老年人表现出减少中顶叶α抑制诱导的时间定向以及减少后α激活与空间定向和冲突解决。总而言之，研究结果与老年人与任务相关的α活动的整体减少一致，并提供了功能证据，表明年轻人和老年人在注意力功能期间以不同的振荡频率参与不同的大脑回路。(C)2013 Elsevier Inc. All rights reserved.
Visual attention depends on bottom-up sensory activation and top-down attentional guidance. Although aging is known to affect sensory processing, its impact on the top-down control of attention remains a matter of debate. We investigated age-related modulations of brain oscillatory activity during visual attention using a variant of the attention network test (ANT) in 20 young and 28 elderly adults. We examined the EEG oscillatory responses to warning and target signals, and explored the correlates of temporal and spatial orienting as well as conflict resolution at target presentation. Time-frequency analysis was performed between 4 and 30 Hz, and the relationship between behavioral and brain oscillatory responses was analyzed. Whereas temporal cueing and conflict had similar reaction time effects in both age groups, spatial cueing was more beneficial to older than younger subjects. In the absence of cue, posterior alpha activation was drastically reduced in older adults, pointing to an age-related decline in anticipatory attention. Following both cues and targets, older adults displayed pronounced motor-related activation in the low beta frequency range at the expense of attention-related posterior alpha activation prominent in younger adults. These findings support the recruitment of alternative motor-related circuits in the elderly, in line with the dedifferentiation hypothesis. Furthermore, older adults showed reduced midparietal alpha inhibition induced by temporal orienting as well as decreased posterior alpha activation associated with both spatial orienting and conflict resolution. Altogether, the results are consistent with an overall reduction of task-related alpha activity in the elderly, and provide functional evidence that younger and older adults engage distinct brain circuits at different oscillatory frequencies during attentional functions. (C) 2013 Elsevier Inc. All rights reserved.