Adherence to combination antiretroviral therapies in HIV patients of low health literacy
Adherence to combination antiretroviral therapies in HIV patients of low health literacy
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DOI：
10.1046/j.1525-1497.1999.00334.x
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发表时间：
1999-05-01
影响因子：
5.7
通讯作者：
Catz, S
中科院分区：
文献类型：
--
作者：
Kalichman, SC;Ramachandran, B;Catz, S
目的：检验健康素养相对于艾滋病毒和艾滋病治疗依从性的其他预测因素的重要性。参与者：目前正在接受抗逆转录病毒三联疗法治疗HIV感染的HIV血清阳性男性（n = 138）和女性（n = 44）的社区样本；60%是少数民族，73%被诊断患有艾滋病。测量：成人健康素养测试（TOFHLA）的一种改编形式，一个全面的健康和治疗访谈，包括每天对治疗依从性和不依从性的回忆，以及药物滥用、社会支持、情绪困扰和对初级保健提供者的态度的测量。主要结果：多元logistic回归显示，在控制了年龄、种族、收入、HIV症状、药物滥用、社会支持、情绪困扰和对初级保健提供者的态度后，教育程度和健康素养是每日治疗依从性的显著独立预测因子。识字率低的人更有可能因为困惑、抑郁而错过治疗剂量。与健康素养较高的参与者相比，他们更渴望清洁自己的身体。结论：需要采取干预措施来帮助低识字率人群坚持抗逆转录病毒治疗。
OBJECTIVE: To test the significance of health literacy relative to other predictors of adherence to treatment for HIV and AIDS.PARTICIPANTS: Community sample of HIV-seropositive men (n = 138) and women (n = 44) currently taking a triple-drug combination of antiretroviral therapies for HIV infection; 60% were ethnic minorities, and 73% had been diagnosed with AIDS.MEASUREMENTS: An adapted form of the Test of Health Literacy in Adults (TOFHLA), a comprehensive health and treatment interview that included a-day recall of treatment adherence and reasons for nonadherence, and measures of substance abuse, social support, emotional distress, and attitudes toward primary care providers.MAIN RESULTS: Multiple logistic regression showed that education and health literacy were significant and independent predictors of a-day treatment adherence after controlling for age, ethnicity, income, HIV symptoms, substance abuse, social support, emotional distress, and attitudes toward primary care providers. Persons of low literacy were more likely to miss treatment doses because of confusion, depression. and desire to cleanse their body than were participants with higher health literacy.CONCLUSIONS: Interventions are needed to help persons of low literacy adhere to antiretroviral therapies.