p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6
p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6
复制标题
对香豆酸通过激活 mTORC1-RPS6 介导的棕色脂肪组织中的生热作用来预防肥胖
DOI：
10.1096/fj.202000333r
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发表时间：
2020-04-29
期刊：
影响因子：
4.8
通讯作者：
Huang, Weidong
中科院分区：
文献类型：
--
作者：
Han, Xue;Guo, Jielong;Huang, Weidong
棕色脂肪组织（brownadipose tissue，BAT）是一种重要的能量消耗器官，也是对抗代谢紊乱的可能靶点。尽管许多研究已经证明了植物化学酚酸通过激活BAT来改善肥胖的能力，但其中的潜在机制或机制仍然不清楚。在这项研究中，饮食诱导的肥胖小鼠，遗传性肥胖小鼠和C3 H10 T1/2细胞被用来检查对香豆酸（CA）的代谢谱的影响。结果表明，CA通过激活BAT来预防两种小鼠模型的代谢综合征。这一现象与解偶联蛋白1（UCP 1）的上调以及脂肪酸和葡萄糖的加速燃烧密切相关，从而增加了能量消耗和产热。在体外也获得了类似的结果。重要的是，这些作用是由雷帕霉素复合物1（mTORC 1）-RPS 6通路的哺乳动物靶介导的。据我们所知，这些发现首次揭示了mTORC 1-RPS 6与BAT介导的产热之间的密切相关性，此外，mTORC 1-RPS 6在介导酚酸诱导的BAT活化中发挥了关键作用，从而预防肥胖。
Brown adipose tissue (BAT) has long been recognized as an energy-consuming organ and a possible target for combating metabolism disorder. Although numerous studies have demonstrated the ability of phytochemical phenolic acids to improve obesity by activating BAT, the underlying mechanism or mechanism therein remain obscure. In this study, diet-induced obese mice, genetically obese mice, and C3H10T1/2 cells were used to examine the effects of p-Coumaric acid (CA) on metabolism profiles. The results showed that CA prevented metabolic syndromes in the two mice models through the activation of BAT. This phenomenon was closely linked to the upregulation of uncoupling protein 1 (UCP1) and the accelerated burning of fatty acids and glucose, which consequently enhanced the energy expenditure and thermogenesis. Similar results were also obtained in vitro. Importantly, these effects were mediated by the mammalian target of rapamycin complex 1 (mTORC1)-RPS6 pathway. These findings reveal, to the best of our knowledge for the first time, the close correlation between mTORC1-RPS6 and BAT-mediated thermogenesis, and, in addition, the key role played by mTORC1-RPS6 in mediating phenolic acids-induced activation of BAT, thus preventing obesity.