A subset of progesterone target neurons have axonal projections to the midbrain.
A subset of progesterone target neurons have axonal projections to the midbrain.
复制标题
黄体酮靶神经元的一个子集具有到中脑的轴突投射。
DOI：
10.1016/0006-8993(90)91545-r
复制
发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Morrell,JI
中科院分区：
文献类型：
--
作者：
DonCarlos,LL;Morrell,JI
应用类固醇激素放射自显影-逆行轴突追踪技术，对雌性大鼠视前区和下丘脑投射至中脑的孕激素集中神经元进行了鉴定。在下丘脑室周围视前区和内侧视前核，以及腹内侧核和弓状核中，预后靶神经元最丰富。在视前内侧区作为一个整体，约14%的孕激素集中细胞传入中脑。更具体地说，23%的内侧视前核孕酮靶神经元直接与中脑细胞群，而一个小得多的百分比（2%）的脑室周围视前靶神经元投射到中脑。在内侧基底下丘脑作为一个整体，11%的孕激素集中细胞检测发送轴突到中脑。这一比例在腹内侧核略高（15%），而在弓状核则低得多（3%）。在背侧和外侧下丘脑区，接近30%的孕酮靶神经元向中脑发出轴突，尽管后两个区域的靶细胞总数和密度较低。这些数据支持这样的观点，即通过前脑靶神经元将孕酮信号转导成中脑中改变的突触传递是孕酮可以影响各种行为的一种途径。
Progestin-concentrating neurons in the preoptic area and hypothalamus that project to the midbrain in the female rat were identified using the combined steroid hormone autoradiography-retrograde axonal tracing technique. Progesterone target neurons were most abundant in the periventricular preoptic area and the medial preoptic nucleus, and in the ventromedial and arcuate nuclei of the hypothalamus. In the medial preoptic area as a whole, about 14% of the progestin-concentrating cells were afferent to the midbrain. More specifically, 23% of medial preoptic nucleus progesterone target neurons communicated directly with midbrain cell groups, whereas a much smaller percentage (2 %) of periventricular preoptic target neurons projected to the midbrain. In the medial basal hypothalamus as a whole, 11% of the progestin-concentrating cells detected sent axons to the midbrain. This proportion was slightly higher in the ventromedial nucleus (15%), and much lower in the arcuate nucleus(3%). In the dorsal and lateral hypothalamic areas, close to 30% of the progesterone target neurons sent axons to the midbrain, although the total number and density of target cells in the two latter areas was low. These data support the idea that transduction by forebrain target neurons of the progesterone signal into altered synaptic transmission in the midbrain is one route through which progesterone can influence a variety of behaviors.