A comparative study of the effects of pulse parameters for intracranial direct electrical stimulation in epilepsy
A comparative study of the effects of pulse parameters for intracranial direct electrical stimulation in epilepsy
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DOI：
10.1016/j.clinph.2015.02.013
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发表时间：
2016-01-01
影响因子：
4.7
通讯作者：
Barborica, Andrei
中科院分区：
文献类型：
--
作者：
Donos, Cristian;Mindruta, Ioana;Barborica, Andrei
目的：颅内直接电刺激（iDES）使用不同的参数来标测耐药性癫痫患者的致痫区和功能区。我们的目的是找到共同的因素驱动的电描记反应，以各种iDES protocols reported in the literature.Methods：我们记录了早期的反应，单脉冲iDES在11例受试者进行立体脑电图术前评估。我们系统地探讨了几个脉冲参数在诱发反应中的作用：单相与双相脉冲，电流强度和脉冲持续时间。我们进行了相关性和回归分析不同协议的振幅，持续时间，和每个phase.Results的收费之间的响应：回归分析显示，响应是相似的，每个阶段相同的收费，无论其脉冲的持续时间和振幅。百分之八十以上当以每相的电荷表示刺激强度时，根据脉冲极性，对可变脉冲持续时间双相刺激的反应的82.8%和对单相刺激的反应的58.6%和81.9%之间与由可变幅度双相协议引起的反应相关。无论不同的刺激电流的组合，它是每相参数的基本电荷，确定的响应的大小，以单脉冲电stimulation.Significance：我们的研究结果提供了一个统一的方法比较iDES协议。(C)2015年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objectives: Intracranial direct electrical stimulation (iDES) uses different parameters for mapping the epileptogenic and functional areas in patients with drug-resistant epilepsy. We aim at finding the common factor driving the electrographic responses to various iDES protocols reported in the literature.Methods: We recorded early responses to single-pulse iDES in 11 subjects undergoing stereoelectroencephalographic presurgical evaluation. We systematically explored the role of several pulse parameters in evoking responses: monophasic versus biphasic pulses, current intensity, and pulse duration. We performed a correlation and regression analysis between responses to different protocols by amplitude, duration, and charge per phase.Results: Regression analysis revealed that the responses were similar for the same charge per phase, regardless of their pulse duration and amplitude. Over eighty percent (82.8%) of the responses to variable pulse duration biphasic stimulation and between 58.6% and 81.9% of the responses to monophasic stimulation, depending on pulse polarity, were correlated to the responses evoked by the variable amplitude biphasic protocol, when expressing stimulus strength in terms of charge per phase.Conclusions: Regardless of the combination of different stimulation currents, it is the underlying charge per phase parameter that determines the magnitude of the responses to single-pulse electrical stimulation.Significance: Our results provide a unifying method for comparing iDES protocols. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.