Evolutionary innovations of human cerebral cortex viewed through the lens of high‐throughput sequencing
Evolutionary innovations of human cerebral cortex viewed through the lens of high‐throughput sequencing
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DOI：
10.1002/dneu.22893
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发表时间：
2022-06
影响因子：
3
通讯作者：
Ikuo K. Suzuki
中科院分区：
文献类型：
--
作者：
Ikuo K. Suzuki
人类在进化过程中获得了一个巨大的大脑皮层，包含大量和各种各样的细胞。这种进化的独特性为我们的认知创新提供了神经基础，也为神经发育和精神疾病的人类特有特征提供了神经基础。由于人类大脑很难在体内进行研究，通常应用于动物模型的实验方法，最近的测序技术的进步提供了一个不可或缺的观点，人类大脑的解剖和发展。本文介绍了近年来基于高通量DNA测序技术对成人大脑皮层的独特特征和特征性发育过程的研究结果。
Humans had acquired a tremendously enlarged cerebral cortex containing a huge quantity and variety of cells during evolution. Such evolutionary uniqueness offers a neural basis of our cognitive innovation and human‐specific features of neurodevelopmental and psychiatric disorders. Since human brain is hardly examined in vivo with experimental approaches commonly applied on animal models, the recent advancement of sequencing technologies offers an indispensable viewpoint of human brain anatomy and development. This review introduces the recent findings on the unique features in the adult and the characteristic developmental processes of the human cerebral cortex, based on high‐throughput DNA sequencing technologies.