Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness
Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness
复制标题
基于非处方组胺 H1 受体拮抗剂对过敏原诱导鼻高反应性小鼠模型的影响重新评估
DOI：
10.1016/j.jphs.2022.10.004
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
O.
中科院分区：
文献类型：
--
作者：
Uda;N.;Ogata;S.;Yamasaki;N.;Miura;S.;Hosomi;N.;Mori;A.;Goto;M.;Miura;K.;and Kaminuma;O.
T细胞在过敏原诱导的鼻高反应性（NHR）（变应性鼻炎的病理生理反应）的发展中起着至关重要的作用。研究了组胺H1受体拮抗剂（抗组胺药）对小鼠NHR模型的影响。依匹斯汀、非索非那定和氯雷他定灌胃给药可抑制免疫小鼠中过敏原诱导的即刻鼻反应，但不能抑制NHR。尽管体外试验中氯雷他定和地氯雷他定可缓解刺激诱导的Th2细胞因子表达，但体内试验中氯雷他定对Th2细胞转移小鼠过敏原诱导的NHR和鼻内嗜酸性粒细胞浸润无影响。这种对T细胞介导的NHR的影响被排除在抗组胺药的药理作用之外。
T cells play an essential role in the development of allergen-induced nasal hyperresponsiveness (NHR), a pathophysiological response in allergic rhinitis. The effects of histamine H1-receptor antagonists (antihistamines) on murine NHR models were investigated. Intragastric epinastine, fexofenadine, and loratadine administration suppressed allergen-induced immediate nasal response but not NHR in immunized mice. Regardless of the alleviation of stimulation-induced Th2 cytokine expression by loratadine and desloratadinein vitro, allergen-induced NHR and nasal eosinophil infiltration in Th2 cell–transferred mice were unaffected by loratadinein vivo. This influence on T cell–mediated NHR was excluded from the pharmacological effects of antihistamines.