Effect of carbachol and cyclic GMP on susceptibility to ventricular fibrillation.
Effect of carbachol and cyclic GMP on susceptibility to ventricular fibrillation.
复制标题
卡巴胆碱和环 GMP 对心室颤动易感性的影响。
DOI：
10.1096/fasebj.4.6.2156744
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Billman,GE
中科院分区：
文献类型：
--
作者：
Billman,GE
心脏迷走神经张力降低已被证明与心室颤动（VF）易感性增加相关。如果这些迷走神经张力的降低导致了室性心动过速，那么可以预测，增加迷走神经张力的干预措施应该可以预防这些致命的心律失常。因此，17只心肌梗死愈合的杂种狗在运动过程中冠脉闭塞2分钟诱导VF。第二天，在运动加缺血试验（n= 14）前给予胆碱能激动剂恰巴醇（20 μg/kg，静脉注射）。Carbachol显著降低了14只动物的心率（对照组为204.5±27.7次/分，对照组为147.0±49.6次/分），并预防了11只动物的VF。当心率下降可以通过心室起搏来预防时，在6只动物中有5只动物中，carbachol可以预防VF。环GMP可能是胆碱能激活的细胞内信使；因此，从运动开始前45分钟开始，在整个运动过程中注射（100‐150 μg·kg−1·min−1，静脉注射）8 -溴环GMP （n= 9）。9只动物中有8只的心率增加，但VF没有发生。二丁基环GMP也有类似的结果（n =5）。这些数据表明胆碱能激动剂和环GMP可以独立于心率变化而预防易感动物的VF。- Billman, g.e.。萘醌和环GMP对心室颤动易感性的影响。中华医学杂志[j] .4: 1668‐1673；1990.
Reductions in cardiac vagal tone have been shown to correlate with increased susceptibility to ventricular fibrillation (VF). If these reductions in vagal tone contribute to VF, one would predict that interventions that increase vagal tone should protect against these lethal arrhythmias. Therefore, VF was induced in 17 mongrel dogs with healed myocardial infarctions by a 2‐min coronary occlusion during exercise. On a subsequent day, the cholinergic agonist carbachol (20 μg/kg, i.v.) was given before the exercise plus ischemia test (n= 14). Carbachol elicited significant reductions in heart rate (control 204.5 ± 27.7 vs. carbachol 147.0 ± 49.6 beats/min) and prevented VF in 11 of 14 animals. When the decline in heart rate was prevented by ventricular pacing, carbachol prevented VF in five of six animals. Cyclic GMP may act as an intracellular messenger of cholinergic activation; therefore, 8‐bromo cyclic GMP (n= 9) was infused (100‐150 μg · kg−1· min−1, i.v.) throughout the exercise beginning 45 min before onset of exercise. Heart rate increased but VF was prevented in eight of nine animals. Similar results were noted for dibutyryl cyclic GMP (n =5). These data suggest that cholinergic agonists and cyclic GMP can prevent VF in susceptible animals independently of heart rate changes.— Billman, G. E. Effect of carbachol and cyclic GMP on susceptibility to ventricular fibrillation.FASEB J.4: 1668‐1673; 1990.