Distalless expression in crustaceans and the patterning of branched limbs
Distalless expression in crustaceans and the patterning of branched limbs
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甲壳类动物的远端表达和分支肢的模式
DOI：
10.1007/s004270050133
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发表时间：
1998
影响因子：
2.4
通讯作者：
T. Williams
中科院分区：
文献类型：
--
作者：
T. Williams
在果蝇中，Distalless （Dll）在建立腿的近端/远端轴中至关重要。缺乏适当的Dll表达会导致远端肢体结构被截断或丢失。通过两种甲壳类动物Triops和Nebalia的四肢发育过程来检测Dll的表达。因为这两个物种的四肢都有分支，它们可以与果蝇的不知名的（无分支的）腿进行比较。在Triops和Nebalia中，分支的发展与Dll表达并不紧密耦合：在某些情况下，分支可以在Dll表达之前出现，而在其他情况下，某些分支从不表达Dll。这些数据表明，虽然Dll可能确实启动了整个肢体的生长，但肢体分支不太可能通过果蝇无分支腿的机制的简单迭代来形成。
Abstract In Drosophila, Distalless (Dll) is critical in establishing the proximal/distal axis of the leg. Lack of proper Dll expression causes distal limb structures to be truncated or lost. Dll expression was examined through the course of development in the limbs of two crustaceans, Triops and Nebalia. Because the limbs of these two species are branched, they provide a comparison to the uniramous (unbranched) leg of Drosophila. In Triops and Nebalia, development of limb branches is not tightly coupled with Dll expression: in some cases, branches can arise prior to Dll expression and in others, certain branches never express Dll. These data suggest that, while Dll may indeed initiate overall limb outgrowth, limb branches are unlikely to be patterned by a simple iteration of the mechanism patterning the unbranched leg of Drosophila.