Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
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DOI：
10.1016/j.nbd.2007.01.008
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发表时间：
2007-05-01
影响因子：
6.1
通讯作者：
Martinez, Salvador
中科院分区：
文献类型：
--
作者：
Cabanes, Carmen;Bonilla, Sonia;Martinez, Salvador
退行性脊髓运动疾病，如肌萎缩侧索硬化症，是由运动神经元的进行性退化引起的。他们的临床表现包括进行性肌肉无力和萎缩，导致瘫痪和过早死亡。目前的药物治疗无法阻止运动缺陷的进展或恢复运动功能。我们研究的目的是探讨将小鼠成年造血干细胞（hSC）移植到运动神经元变性小鼠模型的脊髓中可能产生的有益作用。我们的结果表明，移植的 hSC 在脊髓中存活。此外，移植脊髓中同一脊髓节段的运动神经元数量比未移植的 mdf 小鼠要多，重要的是，运动功能显着改善。这些效应可以通过移植细胞产生的宿主运动神经元周围的胶质细胞系衍生神经营养因子（GDNF）水平增加来解释。因此，这些实验证明了成人 hSC 在所用模型中的神经保护作用，并表明这种细胞类型可能有助于改善退行性脊髓运动疾病的运动功能。 (c) 2007 Elsevier Inc. 保留所有权利。
Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of motoneurons. Their clinical manifestations include a progressive muscular weakness and atrophy, which lead to paralysis and premature death. Current pharmacological therapies fail to stop the progression of motor deficits or to restore motor function. The purpose of our study was to explore the possible beneficial effect of mouse adult hematopoietic stem cells (hSCs) transplanted into the spinal cord of a mouse model of motoneuron degeneration. Our results show that grafted hSCs survive in the spinal cord. In addition, the number of motoneurons in the transplanted spinal cord is larger than in non-transplanted mdf mice at the same spinal cord segments and importantly, motor function significantly improves. These effects can be explained by the increased levels of glial cell line derived neurotrophic factor (GDNF) around host motoneurons produced by the grafted cells. Thus, these experiments demonstrate the neuroprotective effect of adult hSCs in the model employed and indicate that this cell type may contribute to ameliorating motor function in degenerative spinal motor diseases. (c) 2007 Elsevier Inc. All rights reserved.