Peripheral ghrelin treatment stabilizes body weights of senescent male Brown Norway rats at baseline and after surgery.
Peripheral ghrelin treatment stabilizes body weights of senescent male Brown Norway rats at baseline and after surgery.
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外周生长素释放肽治疗可稳定衰老雄性棕色挪威大鼠在基线和手术后的体重。
DOI：
10.1152/ajpregu.00035.2008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Wolden-Hanson,Tami
中科院分区：
文献类型：
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作者：
Yukawa,Michi;Weigle,DavidS;Davis,CharlesD;Marck,BrettT;Wolden-Hanson,Tami
意外的体重减轻可能会自发地发生在老年人和动物身上。老年患者在手术或疾病后体重进一步减轻导致发病率、死亡率和再入院率增加。越来越多的研究表明，食欲增加和体重增加是对胃饥饿激素（ghrelin）的反应。我们在衰老的雄性Brown Norway大鼠中进行了两项研究，以评估外周施用ghrelin增加体重和食物摄入的能力。一项研究评估了在基线条件下每天皮下注射生长素释放肽（1 mg·kg-1·day-1）2周对衰老大鼠的影响;第二项研究在干预实验中使用了相同的给药方案，老年大鼠接受了失血量为10-15%的手术，作为择期手术的模型。在这两项研究中，接受ghrelin的动物保持了体重，而对照组动物体重减轻。在两个实验中，尽管每日或累积食物摄入量没有增加，但在生长素释放肽处理的动物中实现了体重稳定。在手术前和治疗14天后测量激素和促炎细胞因子水平。生长素释放肽治疗似乎钝化了生长素释放肽水平的下降，也钝化了手术对照组中观察到的细胞因子的增加。外周生长素释放肽治疗维持衰老大鼠体重而不伴随食物摄入增加的能力可能是由于其已知的降低交感神经活性和代谢率的能力，可能是通过限制精氨酸驱动的炎症。
Unintentional weight loss may occur spontaneously in older humans and animals. Further weight losses after surgery or illness in the older patients result in increased morbidity, mortality, and hospital readmission rate. A growing body of work has shown increased appetite and weight gain in response to administration of ghrelin, the “hunger hormone.” We conducted two studies in senescent male Brown Norway rats to assess the ability of peripheral administration of ghrelin to increase body weight and food intake. One study assessed the effect of 2 wk of daily subcutaneous ghrelin administration (1 mg·kg−1·day−1) to senescent rats in a baseline condition; a second study used the same administration protocol in an interventional experiment with aged rats subjected to a surgery with 10–15% blood loss as a model of elective surgery. In both studies, animals receiving ghrelin maintained their body weights, whereas control animals lost weight. Body weight stability was achieved in ghrelin-treated animals despite a lack of increase in daily or cumulative food intake in both experiments. Hormone and proinflammatory cytokine levels were measured before surgery and after 14 days of treatment. Ghrelin treatment appeared to blunt declining ghrelin levels and also to blunt cytokine increases seen in the surgical control group. The ability of peripheral ghrelin treatment to maintain body weights of senescent rats without concomitant increases in food intake may be due to its known ability to decrease sympathetic activity and metabolic rate, perhaps by limiting cytokine-driven inflammation.