Ubiquitin Ligases in Longevity and Aging Skeletal Muscle.
Ubiquitin Ligases in Longevity and Aging Skeletal Muscle.
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DOI：
10.3390/ijms23147602
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发表时间：
2022-07-09
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
与老龄化有关的疾病的发展和流行给社会带来了全球健康负担。衰老的一个标志是蛋白质稳态的丧失，这部分是由泛素-蛋白酶体系统（UPS）和溶酶体-自噬系统的改变引起的，导致组织（如骨骼肌）中的功能受损和质量维持。在骨骼肌的情况下，功能受损发生在衰老过程的早期，并且依赖于蛋白质抑制机制。UPS在降解错误折叠和聚集的蛋白质中起着关键作用。为了这次审查的目的，我们将讨论UPS系统的作用，在与年龄相关的肌肉质量和功能的损失的背景下。我们强调了E3泛素连接酶在关键组分（例如，线粒体和神经肌肉接头）对骨骼肌功能和衰老的影响至关重要。此外，我们将简要讨论UPS系统对寿命的贡献。通过了解UPS系统作为年龄相关疾病和疾病（如肌肉减少症）中蛋白质稳态网络的一部分，可以做出新的发现，并开发新的干预措施，这将随着年龄的增长而保护肌肉功能并保持生活质量。
The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In the instance of skeletal muscle, the impairment of function occurs early in the aging process and is dependent on proteostatic mechanisms. The UPS plays a pivotal role in degradation of misfolded and aggregated proteins. For the purpose of this review, we will discuss the role of the UPS system in the context of age-related loss of muscle mass and function. We highlight the significant role that E3 ubiquitin ligases play in the turnover of key components (e.g., mitochondria and neuromuscular junction) essential to skeletal muscle function and the influence of aging. In addition, we will briefly discuss the contribution of the UPS system to lifespan. By understanding the UPS system as part of the proteostasis network in age-related diseases and disorders such as sarcopenia, new discoveries can be made and new interventions can be developed which will preserve muscle function and maintain quality of life with advancing age.
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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Ulfhake, Brun
DOI：
10.1016/j.biocel.2014.04.025
发表时间：
2014-08-01
影响因子：
4
作者：
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通讯作者：
Shavlakadze, Tea