Effect of the essential oil from the flowers of Magnolia sieboldii on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 by rat peritoneal macrophages
Effect of the essential oil from the flowers of Magnolia sieboldii on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 by rat peritoneal macrophages
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DOI：
10.1055/s-2002-32085
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发表时间：
2002-05-01
期刊：
影响因子：
2.7
通讯作者：
Ohuchi, K
中科院分区：
文献类型：
--
作者：
Lim, SS;Shin, KH;Ohuchi, K
研究了厚朴花精油对脂多糖（LPS）诱导大鼠腹腔巨噬细胞产生一氧化氮（NO）和前列腺素E-2 （PGE(2)）的影响。结果表明，其诱导NO和PGE(2)的产生呈浓度依赖性（3-30马克杯/毫升）。气相色谱（GC）和气相色谱/质谱（GC/MS）鉴定了60种化合物，其中-榄香烯（18.0%）、-松油烯（14.83%）和-月桂烯（12.72%）为主要成分，其中-松油烯对lps刺激的大鼠腹腔巨噬细胞产生NO和PGE(2)的抑制作用最明显。
The essential oil from the flowers of Magnolia sieboldii was tested for its effects on lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) by rat peritoneal macrophages. It was shown to induce the production of NO and PGE(2) in a concentration-dependent manner (3-30 mug/ml). Gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) led to the identification of sixty compounds, of which beta-elemene (18.0%), alpha-terpinene (14.83%) and beta-myrcene (12.72%) were the major constituents, Among these three compounds, alpha-terpinene was found to be the most effective one with inhibitory activity on NO and PGE(2) production by LPS-stimulated rat peritoneal macrophages.