Targeting the bone marrow in Waldenstrom macroglobulinemia.
Targeting the bone marrow in Waldenstrom macroglobulinemia.
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DOI：
10.1016/j.clml.2011.03.022
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Roccaro, Aldo M
中科院分区：
文献类型：
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作者：
Ghobrial, Irene M;Zhang, Yong;Roccaro, Aldo M
华氏巨球蛋白血症 (WM) 是一种低度 B 细胞淋巴瘤，其特征是淋巴浆细胞广泛累及骨髓。在大约 20% 的患者中，恶性克隆还累及淋巴结并引起肝脾肿大。肿瘤细胞归巢于骨髓并优先驻留在骨髓微环境中的机制尚未完全阐明。在这篇综述中，我们研究了骨髓微环境在调节 WM 细胞生长、存活和细胞传播中的作用。我们还总结了 WM 中生态位依赖性肿瘤增殖的具体调节因子。这些包括趋化因子、粘附分子、Src/PI3K/Akt/mTOR 信号传导、NF-kB 激活和 WM 中的 micro-RNA 调节。在临床试验中针对这些途径可能会对这种罕见疾病产生显着的反应。
Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.