Intravascular Photoacoustic Imaging.
Intravascular Photoacoustic Imaging.
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DOI：
10.1109/jstqe.2009.2037023
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发表时间：
2010-06-03
影响因子：
2.5
通讯作者：
Emelianov SY
中科院分区：
文献类型：
--
作者：
Wang B;Su JL;Karpiouk AB;Sokolov KV;Smalling RW;Emelianov SY
血管内光声（IVPA）成像是一种基于导管的微创成像方式，能够提供动脉壁的高分辨率光学吸收图。与血管内超声（IVUS）成像集成，组合的IVPA和IVUS成像可用于检测和表征动脉内膜中积聚的动脉粥样硬化斑块。在本文中，我们提出并讨论了各种代表性的应用相结合的IVPA/IVUS成像动脉粥样硬化，包括动脉粥样硬化斑块的成分的评估，斑块内的巨噬细胞的成像，与斑块的形成和发展相关的生物标志物的分子成像。此外，使用IVPA和IVUS成像的冠状动脉支架的成像被证明。此外，一个集成的IVUS/IVPA成像导管需要在体内临床应用的设计进行了讨论。
Intravascular photoacoustic (IVPA) imaging is a catheter-based, minimally invasive, imaging modality capable of providing high-resolution optical absorption map of the arterial wall. Integrated with intravascular ultrasound (IVUS) imaging, combined IVPA and IVUS imaging can be used to detect and characterize atherosclerotic plaques building up in the inner lining of an artery. In this paper, we present and discuss various representative applications of combined IVPA/IVUS imaging of atherosclerosis, including assessment of the composition of atherosclerotic plaques, imaging of macrophages within the plaques, and molecular imaging of biomarkers associated with formation and development of plaques. In addition, imaging of coronary artery stents using IVPA and IVUS imaging is demonstrated. Furthermore, the design of an integrated IVUS/IVPA imaging catheter needed for in vivo clinical applications is discussed.