Assessment of an extracorporeal liver assist device in anhepatic dogs.
Assessment of an extracorporeal liver assist device in anhepatic dogs.
复制标题
无肝犬体外肝脏辅助装置的评估。
DOI：
10.1111/j.1525-1594.1992.tb00543.x
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发表时间：
1992
影响因子：
2.4
通讯作者：
Sussman,NL
中科院分区：
文献类型：
--
作者：
Kelly,JH;Koussayer,T;He,D;Chong,MG;Shang,TA;Whisennand,HH;Sussman,NL
我们已经使用了一个无肝狗模型，以证明生物人工肝辅助装置的有效性。6只犬行全肝切除术。三个只接受医疗护理（对照组），而其余的则连接到体外肝脏辅助装置（ELAD）。对照组麻醉后均未苏醒，但术后4-5 h存活。从手术结束到动物死亡，血浆氨浓度平均增加2-50 μmol/L。接受治疗的狗存活了3-12.5小时，其中2只需要重复给予硫戊巴比妥钠来维持镇静。血浆氨浓度不变后，连接到ELAD，但在最长的幸存者，其氨开始上升后8小时的ELAD。另外2只给药犬的短期存活是由于不受控制的腹腔内出血。该装置能够替代肝脏的代谢功能，并可能为等待移植或暴发性肝功能衰竭的患者提供肝脏支持。
We have used an anhepatic dog model to demonstrate the efficacy of a bioartificial liver assist device. Six dogs underwent total hepatectomy. Three received only medical care (controls) while the remainder were connected to an extracorporeal liver assist device (ELAD). The control dogs failed to regain consciousness after anesthesia although all lived 4–5 h postoperativlely. Plasma ammonia concentration increased by an average of 2–50 μmol/L between the end of surgery and the demise of the animals. The treated dogs lived 3–12.5 h, and 2 of them required repeated doses of thiamylal sodium to maintain sedation. Plasma ammonia concentration was unchanged after connection to the ELAD except in the longest survivor, whose ammonia began to rise after 8 h on the ELAD. The short survival in the other 2 treated dogs was the result of uncontrolled intraabdominal bleeding. This device is capable of replacing the metabolic function of the liver, and might provide hepatic support in patients awaiting transplantation or in fulrninant hepatic failure.