THE SEGMENT POLARITY GENE ARMADILLO ENCODES A FUNCTIONALLY MODULAR PROTEIN THAT IS THE DROSOPHILA HOMOLOG OF HUMAN PLAKOGLOBIN
THE SEGMENT POLARITY GENE ARMADILLO ENCODES A FUNCTIONALLY MODULAR PROTEIN THAT IS THE DROSOPHILA HOMOLOG OF HUMAN PLAKOGLOBIN
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DOI：
10.1016/0092-8674(90)90413-9
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发表时间：
1990-12-21
期刊：
影响因子：
64.5
通讯作者：
WIESCHAUS, E
中科院分区：
文献类型：
--
作者：
PEIFER, M;WIESCHAUS, E
果蝇节段的极性基因Aradillo是在胚胎节段和成像盘中形成图案所必需的。我们发现螳螂在进化过程中高度保守；它与人类白蛋白有63%的同源性，白蛋白是一种在连接上皮细胞和其他细胞的粘连连接中发现的蛋白质。我们研究了ARM蛋白在一些幼虫组织中的定位，发现ARM蛋白在细胞内的积累与蛋白的积累有许多相似的特征。我们比较了导致不同手臂突变的表型和分子损伤。令人惊讶的是，严重截短的蛋白质保留了一些功能；功能的程度与截短的蛋白质的长度严格相关，这表明内部重复的手臂蛋白质在功能上是模块化的。我们为ARM的细胞作用提出了一个可能的模型。
The Drosophila segment polarity gene armadillo is required for pattern formation within embryonic segments and imaginal discs. We have found that armadillo is highly conserved during evolution; it is 63% identical to human plakoglobin, a protein found in adhesive junctions joining epithelial and other cells. We have examined arm protein localization in a number of larval tissues and found that arm protein accumulation within cells shares many features with the accumulation of plakoglobin. We have compared the phenotype and molecular lesions responsible for the different arm mutations. Surprisingly, severely truncated proteins retain some function; the degree of function is strictly correlated with the length of the truncated protein, suggesting that the internally repetitive arm protein is modular in function. We present a possible model for the cellular role of arm.