Multimodal network dynamics underpinning working memory
Multimodal network dynamics underpinning working memory
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DOI：
10.1038/s41467-020-15541-0
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发表时间：
2020-06-15
影响因子：
16.6
通讯作者：
Bassett, Danielle S.
中科院分区：
文献类型：
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作者：
Murphy, Andrew C.;Bertolero, Maxwell A.;Bassett, Danielle S.
复杂的人类认知是多个大脑系统综合处理的结果。然而，关于大脑系统及其相互作用如何与人类认知能力相关，甚至可能解释这一点，人们知之甚少。在这里，我们通过提出一个机制框架来解决这一知识差距，该框架将额顶系统活动、默认模式系统活动以及它们之间的相互作用与工作记忆容量的个体差异联系起来。我们发现，工作记忆的表现取决于额顶和默认模式系统之间的功能相互作用的强度。我们发现，这种强度受到两个新描述的大脑区域的激活的调节，并证明了这些系统的功能作用是由结构性白质支撑的。总的来说，我们的研究全面描述了区域活动、功能联系和结构联系如何共同支持大脑系统的整合处理，以便大脑执行复杂的认知过程。
Complex human cognition arises from the integrated processing of multiple brain systems. However, little is known about how brain systems and their interactions might relate to, or perhaps even explain, human cognitive capacities. Here, we address this gap in knowledge by proposing a mechanistic framework linking frontoparietal system activity, default mode system activity, and the interactions between them, with individual differences in working memory capacity. We show that working memory performance depends on the strength of functional interactions between the frontoparietal and default mode systems. We find that this strength is modulated by the activation of two newly described brain regions, and demonstrate that the functional role of these systems is underpinned by structural white matter. Broadly, our study presents a holistic account of how regional activity, functional connections, and structural linkages together support integrative processing across brain systems in order for the brain to execute a complex cognitive process.