Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering
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结合荧光纳米传感器的电纺 PLGA 纤维片:用于组织工程应用的自我报告支架

DOI:
10.1039/c2ay25771h
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发表时间:
2013
期刊:
Anal. Methods
影响因子:
--
通讯作者:
Harrington H
Harrington H
中科院分区:
--
文献类型:
--
作者:
Harrington H

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比例分析物响应纳米传感器已被纳入电纺聚乳酸-乙醇酸 (PLGA) 纤维中,以创建自我报告支架。已经证明,自我报告支架可用于监测微环境条件,而不会损坏制造的支架或在构建体上培养的细胞。这为充分理解、监测和优化 3D 模型组织结构的体外生长提供了机会。
Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor microenvironment conditions without damaging the fabricated scaffold or the cells being cultured upon the construct. This presents opportunities to fully understand, monitor and optimise the growth of 3D model tissue constructs in vitro.
使用光学成像系统原位监测 3D 体外细胞聚集
DOI: --
发表时间: 2008
影响因子: 3.8
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