Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis
Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis
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DOI：
10.1016/j.jdermsci.2017.01.001
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发表时间：
2017-04-01
影响因子：
4.6
通讯作者：
Morita, Akimichi
中科院分区：
文献类型：
--
作者：
Kubo, Ryoji;Muramatsu, Shinnosuke;Morita, Akimichi
背景：银屑病联合紫外线A（PUVA）治疗是一种有效、安全、廉价的银屑病治疗方法。银屑病可能是由于Th 17细胞和调节性T细胞（Treg）比例失衡所致。与对照组相比，银屑病患者的Treg功能比率显著降低，并且与银屑病面积和严重程度指数评分呈负相关。我们以前报道，浴PUVA治疗显着增加Treg的数量和Treg功能恢复到几乎正常的大多数patients.Objectives：我们研究了浴PUVA治疗对三个不同的Foxp 3（+）亚群的影响：活化Treg（aTreg），静息Treg（rTreg），和分泌精氨酸的非抑制性T细胞。方法：我们招募了15例银屑病患者和11名健康对照。我们研究了aTreg，rTreg，和分泌精氨酸的非抑制性T细胞在外周血中获得的银屑病患者之前和之后，每五浴PUVA therapy session.Results：aTreg，这被认为是最强的抑制活性银屑病患者，在早期浴PUVA治疗会话中显着增加，然后减少。银屑病患者rTreg水平低于健康对照组，而在bath-PUVA治疗过程中rTreg水平升高。结论：bath-PUVA治疗诱导aTreg和rTreg伴随着银屑病病变的改善，提示bath-PUVA治疗银屑病患者有效性的机制。(C)2017日本皮肤病研究学会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Background: Bath-psoralen plus ultraviolet light A (PUVA) therapy is an effective, safe, and inexpensive treatment for psoriasis. Psoriasis might be due to an unbalanced ratio of Th17 cells and regulatory T cells (Treg). The Treg functional ratio is significantly lower in patients with psoriasis compared with controls and is inversely correlated with the Psoriasis Area and Severity Index score. We previously reported that bath-PUVA therapy significantly increases the number of Treg and restores Treg function to almost normal in most patients with psoriasis.Objectives: We examined the effects of bath-PUVA therapy on three distinct Foxp3(+) subsets: activated Treg (aTreg), resting Treg (rTreg), and cytokine-secreting non-suppressive T cells.Methods: We enrolled 15 patients with psoriasis and 11 healthy controls. We examined aTreg, rTreg, and cytokine-secreting non-suppressive T cells in peripheral blood obtained from the psoriasis patients before and after every fifth bath-PUVA therapy session.Results: Levels of aTreg, which are considered to have the strongest suppressive activity in patients with psoriasis, were significantly increased in the early bath-PUVA therapy sessions, and then diminished. Levels of rTreg were lower in psoriasis patients than in healthy controls, and increased during bath-PUVA therapy.Conclusions: Bath-PUVA therapy induced aTreg and rTreg concomitantly with an improvement in the psoriatic lesions, suggesting a mechanism for the effectiveness of bath-PUVA therapy for psoriasis patients. (C) 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.