EFFECT OF INDUCED ERYTHROCYTHEMIA ON AEROBIC WORK CAPACITY
EFFECT OF INDUCED ERYTHROCYTHEMIA ON AEROBIC WORK CAPACITY
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DOI：
10.1152/jappl.1980.48.4.636
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
MEYERS, EC
中科院分区：
文献类型：
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作者：
BUICK, FJ;GLEDHILL, N;MEYERS, EC
采用双盲设计对 11 名训练有素的人类跑步者的有氧工作能力进行了研究，在放血前 (C1)、正常细胞增多症恢复后 (C2)、假回输 50 ml 生理盐水后（假）、自体回输约 900 ml 冷冻保存血液后（回输）以及红细胞增多症后重新建立控制血液学水平后（C3）。 C1、C2、假手术和 C3 之间没有血液学差异，但回输后 Hb 显着升高 (15.7-16.7 g .cntdot. 100 ml-1)。再输注后24小时（分别为5.11-5.37升.cntdot.min-1和7.20-9.65分钟）和再输注后7天，最大O2消耗量（.ovrhdot.VO2 max）和跑至力竭的时间显着增加。当假手术在再输注之前时，.ovrhdot.VO2 max 和力竭时间与对照相同。再输注后16周后，尽管恢复到正常血液学值，但在假手术和C3时.ovrhdot.VO2 max仍显着高于对照水平。显然，在诱导红细胞增多症后，.ovrhdot.VO2 max 明显增加。显然，氧气运输限制了最大有氧能力。
The aerobic work capacity of 11 highly trained human runners was studied employing a double-blind design before phlebotomy (C1), following restoration of normocythemia (C2), after a sham reinfusion of 50 ml of saline (sham), following autologous reinfusion of approximately 900 ml of freeze-preserved blood (reinfusion) and upon reestablishment of control hematologic levels after erythrocythemia (C3). There were no hematologic differences among C1, C2, sham and C3, but following reinfusion Hb was significantly elevated (15.7-16.7 g .cntdot. 100 ml-1). Maximum O2 consumption (.ovrhdot.VO2 max) and running time to exhaustion were significantly increased 24 h postreinfusion (5.11-5.37 l .cntdot. min-1 and 7.20-9.65 min, respectively) and 7 days postreinfusion. When sham preceded reinfusion, .ovrhdot.VO2 max and time to exhaustion were the same as control. After 16 wk postreinfusion, despite the return to normal hematologic values, .ovrhdot.VO2 max remained significantly above control levels at sham and C3. Apparently there is a distinct increase in .ovrhdot.VO2 max following induced erythrocythemia. Apparently O2 transport limits maximal aerobic capacity.