Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese
Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese
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DOI：
10.1097/ypg.0b013e32833a21f9
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发表时间：
2010-06-01
影响因子：
0.9
通讯作者：
Sugimura, Haruhiko
中科院分区：
文献类型：
--
作者：
Sato, Naomi;Kageyama, Shinji;Sugimura, Haruhiko
神经毒素1（NRXN 1，MIM 600565）是在神经元中表达的分子，并且是α-latrotoxin的受体（Rowen et al.，2002年）。Bierut等人（2007）在一项病例对照分析中指出，NRXN 1基因位点是导致尼古丁依赖的原因，该分析的病例是美国和澳大利亚吸烟者，他们的Fagerström尼古丁依赖测试（FTND）评分为4或更高。另一组还记录了NRXN 1基因座的多态性对欧洲-美国和非洲-美国人群中尼古丁依赖的显著贡献（Nussbaum et al.，2008年）。他们评估了欧洲裔美国人和非洲裔美国人吸烟者的21种NRXN 1多态性与FTND评分，每天吸烟数量（CPD）和吸烟指数的严重性的关系，该指数是CPD和一天中第一支烟之前的时间的组合。结果显示，21个单核苷酸多态性中的两个，rs 2193225和rs6721498，与欧洲和非洲血统的一些美国人群的吸烟指数和FTND评分相关。在这封信中，我们报告了这些多态性的评估，在老年日本人口（60-94岁）根据吸烟史。在2516名具有不同吸烟习惯的日本人中对rs6721498和rs 2193225进行基因分型[1612名男性参与者中有1348名曾经吸烟者（目前吸烟者和既往吸烟者; 83.6%），904名女性参与者中有82名（9.1%），目前吸烟者分别占男性和女性参与者的21.6%和3.4%]。烟草依赖筛查仪（TDS）的开发是为了使检测到的特征与《疾病和有关健康问题国际统计分类》第10版（诊断和治疗）所定义的特征更加密切相关。
Neurexin 1 (NRXN1, MIM 600565) is a molecule that is expressed in neurons and is a receptor for α-latrotoxin (Rowen et al., 2002). Bierut et al.(2007) pinpointed the NRXN1 gene locus as being responsible for nicotine dependence in a case–control analysis in which the cases were American and Australian smokers whose Fagerström Test for Nicotine Dependence (FTND) score was 4 or more. The other group also documented a significant contribution of the polymorphism at the NRXN1 locus to nicotine dependence in the European–American and African–American populations (Nussbaum et al., 2008). They evaluated 21 NRXN1 polymorphisms in European–American and African–American smokers for associations with FTND scores, number of cigarettes smoked per day (CPD), and the heaviness of smoking index, which is a combination of CPD and time before the first cigarette of the day. The results showed that two of 21 single nucleotide polymorphisms, rs2193225 and rs6721498, were associated with heaviness of smoking index and FTND scores in some American populations of European and African origin. In this letter, we report the evaluation of these polymorphisms in an elderly Japanese population (60–94 years old) according to smoking history. The rs6721498 and rs2193225 were genotyped in 2516 Japanese with various smoking habits [1348 ever-smokers (current smokers and ex-smokers; 83.6%) among the 1612 male participants and 82 (9.1%) among the 904 female participants, and current smokers were 21.6 and 3.4% of the male and female participants, respectively]. FTND and the Tobacco Dependence Screener (TDS), which was developed so that the characteristics detected would be more closely correlated with those defined by the International Statistical Classification of Diseases and Related Health Problems, 10th version, Diagnostic and