Nutritional Supplementation Is a Necessary Complement to Dietary Counseling among Tuberculosis and Tuberculosis-HIV Patients
Nutritional Supplementation Is a Necessary Complement to Dietary Counseling among Tuberculosis and Tuberculosis-HIV Patients
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DOI：
10.1371/journal.pone.0134785
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发表时间：
2015-08-27
期刊：
影响因子：
3.7
通讯作者：
Rolla, Valeria Cavalcante
中科院分区：
文献类型：
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作者：
Bacelo, Adriana Costa;Ramalho, Andrea;Rolla, Valeria Cavalcante
巴西卫生部和世界卫生组织建议在结核病治疗期间对营养不良的患者进行饮食咨询。结核病治疗的患者（感染和未感染艾滋病毒）进行了随访，以评估饮食咨询的有效性。目的：描述肺结核患者的营养状况。方法：对接受结核病治疗180天的成人进行观察性随访研究。受试者的身体成分（使用BMI，TSF和MUAC参数），血清生物标志物进行评估，并提供饮食咨询。分析每次访视（D15、D30、D 60、D90、D120、D150和D180）时获得的数据，显示随时间推移的轨迹和每次的中心趋势。结果如下：在基线时，平均年龄为41.1（+/- 13.4）岁;他们主要是男性，收入低于当地最低工资，至少受过六年教育。患者主要表现为肺结核。基线时，所有患者均患有营养不良。总的能量营养不良患病率为70.6%。在两组中均观察到基线贫血（63.2%），但在HIV+患者中明显更明显。最后，能量营养不良率降至57.1%（艾滋病毒阴性者为42.9%，艾滋病毒阳性者为71.4%）。在结核病治疗结束时，71.4%的HIV-患者和85.7%的HIV+患者存在明显的营养素营养不良。使用BMI（
The Brazilian Ministry of Health and the World Health Organization recommend dietary counseling for patients with malnutrition during tuberculosis treatment. Patients under tuberculosis therapy (infected and not infected with HIV) were followed-up to evaluate the effectiveness of dietary counseling. Objective: describe the nutritional status of patients with tuberculosis. Methods: an observational follow-up study over a 180-day period of tuberculosis therapy in adults was conducted. Subjects were assessed for body composition (using BMI, TSF and MUAC parameters), serum biomarkers and offered dietary counseling. The data obtained at each visit (D15, D30, D60, D90, D120, D150, and D180) were analyzed, showing trajectories over time and central tendencies each time. Results: at baseline, the mean age was 41.1 (+/- 13.4) years; they were predominantly male, with income lower than a local minimum wage and at least six years of schooling. Patients showed predominantly pulmonary tuberculosis. At baseline, all patients suffered from malnutrition. The overall energy malnutrition prevalence was of 70.6%. Anemia at baseline was observed in both groups (63.2%), however, it was significantly more pronounced in the HIV+. At the end, energy malnutrition was reduced to 57.1% (42.9% of HIV- and 71.4% of the HIV+). Micronutrients malnutrition was evident in 71.4% of the HIV-patients and 85.7% of HIV+ patients at the end of tuberculosis therapy. Using BMI (