Effects of environment on enhancing functional plasticity following cerebral ischemia.
Effects of environment on enhancing functional plasticity following cerebral ischemia.
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DOI：
10.1177/109980040000100406
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发表时间：
2000-04-01
影响因子：
2.5
通讯作者：
Metzger, B
中科院分区：
文献类型：
--
作者：
Briones, T L;Therrien, B;Metzger, B
考虑到大脑从损伤中恢复的能力，脑缺血后通过环境操纵可以增强可塑性。因此，本研究的目的是（1）确定缺血后早期暴露于丰富环境对功能可塑性的影响，（2）检查形态和行为可塑性之间的关系。成年雌性大鼠（n = 38）分为缺血组和对照组。每组进一步随机分配至标准（SC）或富集条件（EC）。环境暴露4天后，在水迷宫中测试大鼠6天。与SC组相比，EC组大鼠海马区树突总长度增加（P <0.05），树突节数增加（P < 0.05），树突棘密度增加（P < 0.05）。行为学测试结果显示，SC组大鼠游泳时间较EC组延长（P < 0.05），定向误差较大（P < 0.05），EC组与对照组相似。它的结论是，EC可能是一个潜在的有用的治疗在缺血后看到的空间记忆障碍的恢复。
Given the brain's capacity to recover from injury, plasticity may be enhanced following cerebral ischemia through environmental manipulation. Thus, the purpose of this study was to (1) determine the effects of early exposure to an enriched environment following ischemia on functional plasticity and (2) examine the relationship between morphological and behavioral plasticity. Adult female rats (n = 38) were divided into ischemia and control groups. Each group was further randomized to either standard (SC) or enriched conditions (EC). After 4 days of environmental exposure, rats were tested for 6 days in the water maze. Control and ischemia rats exposed to EC have increased total dendritic length (P < 0.05) as well as increased number of dendritic segments in the apical (P < 0.05) region of the hippocampal area compared to those housed in SC; furthermore, increased dendritic spine density in the apical (P < 0.05) region was also seen. Behavioral testing showed that ischemia rats exposed to SC have longer swim latencies (P < 0.05) and greater directional heading errors (P < 0.05) than ischemic rats exposed to EC; the latter group performed similar to controls. It is concluded that EC may be a potentially useful therapy in the recovery of spatial memory impairments seen after ischemia.