Maternal serum 25(OH)D levels in the third trimester of pregnancy during the winter season
Maternal serum 25(OH)D levels in the third trimester of pregnancy during the winter season
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DOI：
10.3109/14767058.2011.566768
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发表时间：
2011-12-01
影响因子：
1.8
通讯作者：
Avsar, Ayse Filiz
中科院分区：
文献类型：
--
作者：
Ustuner, Isik;Keskin, H. Levent;Avsar, Ayse Filiz
Objective.测定冬季妊娠晚期孕妇血清25（OH）D水平，探讨其影响因素。2008年11月至2009年3月期间，共对79名妊娠晚期孕妇进行了检查。测定血清钙、磷、碱性磷酸酶、甲状旁腺激素和25（OH）D水平。对孕妇年龄、文化程度、社会经济地位、营养状况、穿衣习惯、日光暴露水平等进行分析，并比较其与血清25（OH）D水平的相关性。研究组孕妇血清25（OH）D平均水平为11.95 ± 7.20 ng/ml，孕妇严重维生素D缺乏[25（OH）D < 10 ng/ml]的患病率为45.6%。未发现严重维生素D缺乏与母亲年龄、妊娠、皮肤光型、受益于紫外线指数和病例的教育状况之间存在关联。在使用多种维生素补充剂和SES良好的患者中，25（OH）D水平也显著较高（分别为p = 0.046，p = 0.025）。这项研究表明，冬季孕妇维生素D缺乏的比例非常高，我们发现补充多种维生素的患者和SES良好的患者维生素D水平较高。
Objective. To measure serum 25(OH) D levels of pregnant women in the last trimester during the winter season and to determine the factors affecting their serum levels.Methods. In all, 79 pregnant women in the third trimester were examined between November 2008 and March 2009. Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25(OH) D levels were measured. Maternal age, education, socioeconomic status (SES), nutrition, dressing habits, and level of sunlight exposure were determined and their correlation with serum 25(OH) D levels were statistically compared.Results. The mean serum 25(OH)D level of the study group was 11.95 +/- 7.20 ng/ml, and the prevalence of severe vitamin D deficiency [25(OH)D < 10 ng/ml] in pregnant women was 45.6%. No association was detected between severe vitamin D deficiency and maternal age, gravidity, skin phototype, benefiting from ultraviolet index, and educational status of the cases. Also in patients who used multivitamin supplements and good SES, 25(OH)D levels were significantly higher (p = 0.046, p = 0.025, respectively).Conclusions. This study showed a remarkable high rate of vitamin D deficiency in pregnant women during the winter season and we have found high levels of vitamin D in patients supplemented with multivitamins and in ones with good SES.