Mean platelet volume: a useful marker of inflammatory bowel disease activity
Mean platelet volume: a useful marker of inflammatory bowel disease activity
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DOI：
10.1111/j.1572-0241.2001.03621.x
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发表时间：
2001-03
影响因子：
9.8
通讯作者：
A. Kapsoritakis;M. Koukourakis;Aekaterini Sfiridaki;S. Potamianos;M. Kosmadaki;I. Koutroubakis;E. Kouroumalis
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文献类型：
--
作者：
A. Kapsoritakis;M. Koukourakis;Aekaterini Sfiridaki;S. Potamianos;M. Kosmadaki;I. Koutroubakis;E. Kouroumalis
目的：我们研究了平均血小板体积是否可以作为评估炎症性肠病活动性的有用指标。方法：测定93例溃疡性结肠炎患者、66例克罗恩病患者和38例健康献血者的全血细胞计数、c反应蛋白、红细胞沉降率、血清血小板生成素和红细胞生成素、血浆β-血小板球蛋白和血小板因子4。通过溃疡性结肠炎患者的临床结肠炎活动指数和克罗恩病患者的克罗恩病活动指数评估疾病活动性。结果：活动性溃疡性结肠炎患者的平均血小板计数高于非活动性溃疡性结肠炎患者（p < 0.05），活动性克罗恩病患者的平均血小板计数高于非活动性克罗恩病患者（p = 0.0002）或健康对照（p < 0.0001）。另一方面，活动性溃疡性结肠炎患者与非活动性溃疡性结肠炎患者相比（p = 0.02）或健康对照（p < 0.0001），活动性克罗恩病患者与非活动性克罗恩病患者相比（p = 0.0005）或健康对照（p < 0.0001）的平均血小板体积显著降低。平均血小板体积与白细胞计数（r = - 0.17, p = 0.02）、c反应蛋白（r = - 0.46, p = 0.009）和红细胞沉降率（r = - 0.28, p = 0.008）呈负相关。平均血小板体积与血清血小板生成素或红细胞生成素水平无显著相关性；然而，平均血小板体积与β-血小板球蛋白（r = - 0.34, p < 0.0001）和血小板因子4 （r = - 0.30, p = 0.0002）呈显著负相关。结论：活动性炎症性肠病患者平均血小板体积显著降低，且与已知炎症性肠病活动性标志物和血小板活化产物呈负相关。我们认为，平均血小板体积提供了炎症性肠病活动的一个有用的标志物。
OBJECTIVES:We investigated whether the mean platelet volume would be a useful marker in the evaluation of inflammatory bowel disease activity.METHODS:Complete blood count, C-reactive protein, erythrocyte sedimentation rate, serum thrombopoietin and erythropoietin, plasma β-thromboglobulin, and platelet factor 4 were measured in 93 patients with ulcerative colitis, 66 patients with Crohn's disease, and 38 healthy blood donors. Disease activity was assessed by the Clinical Colitis Activity Index in patients with ulcerative colitis and by the Crohn's Disease Activity Index in patients with Crohn's disease.RESULTS:Mean platelet count was increased in patients with active compared to inactive ulcerative colitis (p < 0.05), and in patients with active compared to inactive Crohn's disease (p = 0.0002) or healthy controls (p < 0.0001). On the other hand, mean platelet volume was significantly decreased in patients with active compared to inactive ulcerative colitis (p = 0.02) or healthy controls (p < 0.0001), and in patients with active compared to inactive Crohn's disease (p = 0.0005) or healthy controls (p < 0.0001). Mean platelet volume was inversely correlated with the white blood cell count (r =−0.17, p = 0.02), C-reactive protein (r =−0.46, p = 0.009) and erythrocyte sedimentation rate (r =−0.28, p = 0.008). No significant correlations were found between mean platelet volume and serum thrombopoietin or erythropoietin levels; however, a strong negative correlation between mean platelet volume and β-thromboglobulin (r =−0.34, p < 0.0001) and platelet factor 4 (r =−0.30, p = 0.0002) was observed.CONCLUSIONS:Mean platelet volume is significantly reduced in active inflammatory bowel disease and is negatively correlated with the known inflammatory bowel disease activity markers and the platelet activation products. We propose that mean platelet volume provides a useful marker of activity in inflammatory bowel disease.