The Fat-like cadherin CDH-4 controls axon fasciculation, cell migration and hypodermis and pharynx development in Caenorhabditis elegans
The Fat-like cadherin CDH-4 controls axon fasciculation, cell migration and hypodermis and pharynx development in Caenorhabditis elegans
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DOI：
10.1016/j.ydbio.2008.01.024
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发表时间：
2008-04-15
影响因子：
2.7
通讯作者：
Hutter, Harald
中科院分区：
文献类型：
--
作者：
Schmitz, Caroline;Wacker, Irene;Hutter, Harald
钙粘蛋白是主要的粘附分子家族之一，在胚胎发育过程中具有多种功能。脂肪样钙粘蛋白形成一个进化上保守的亚群，其特征是在细胞外区域异常大量的钙粘蛋白重复。在这里，我们描述了脂肪样钙粘蛋白CDH-4在秀丽隐杆线虫发育中的作用。Cdh-4突变体的特点是皮下缺陷，导致不完全渗透的胚胎或幼虫致命，具有可变的形态发生缺陷。除了形态发生缺陷外，cdh-4突变动物还表现出腹侧和背侧脊髓的束状缺损，主要的纵向轴突束，以及Q神经母细胞的迁移缺陷。此外，CDH-4对于建立和维持口腔与咽部之间的连接至关重要。在胚胎发生过程中，Cdh-4在大多数受影响的细胞和组织中广泛表达，这表明Cdh-4在发育过程中起着确保适当的细胞接触的建立和维持的作用。(C) 2008爱思唯尔公司版权所有。
Cadherins are one of the major families of adhesion molecules with diverse functions during embryonic development. Fat-like cadherins form an evolutionarily conserved subgroup characterized by an unusually large number of cadherin repeats in the extracellular domain. Here we describe the role of the Fat-like cadherin CDH-4 in Caenorhabditis elegans development. Cdh-4 mutants are characterized by hypodermal defects leading to incompletely penetrant embryonic or larval lethality with variable morphogenetic defects. Independently of the morphogenetic defects cdh-4 mutant animals also exhibit fasciculation defects in the ventral and dorsal cord, the major longitudinal axon tracts, as well as migration defects of the Q neuroblasts. In addition CDH-4 is essential for establishing and maintaining the attachment between the buccal cavity and the pharynx. Cdh-4 is expressed widely in most affected cells and tissues during embryogenesis suggesting that CDH-4 functions to ensure that proper cell contacts are made and maintained during development. (C) 2008 Elsevier Inc. All rights reserved.