Asymmetric Total Synthesis of Propindilactone G, Part 1: Initial Attempts towards the Synthesis of Schiartanes
Asymmetric Total Synthesis of Propindilactone G, Part 1: Initial Attempts towards the Synthesis of Schiartanes
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Propindilactone G 的不对称全合成，第 1 部分：合成五十子烷的初步尝试
DOI：
10.1002/asia.201600129
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发表时间：
2016
影响因子：
4.1
通讯作者：
Yang Zhen
中科院分区：
文献类型：
--
作者：
Xu Ling-Ming;You Lin;Shan Zhen-Hua;Yu Ruo-Cheng;Zhang Bo;Li Yuan-He;Shi Ying;Chen Jia-Hua;Yang Zhen
报道了丙二内酯G（1）及其类似物的第一代全合成研究。合成的关键步骤是分子内Pauson-Khand反应（PKR）和乙烯基Mukaiyama反应（VMAR）。通过PKR立体选择性合成具有全碳季中心的CDE环部分是困难的，而VMAR提供在侧链上的C20位置具有相反立体化学的产物。这些结果使我们重新设计了化合物1的全合成策略。
Our first‐generation synthetic study towards the total synthesis of propindilactone G (1) and its analogues is reported. The key synthetic steps were an intramolecular Pauson–Khand reaction (PKR) and a vinylogous Mukaiyama reaction (VMAR). The stereoselective synthesis of the CDE ring moiety with an all‐carbon quaternary center through a PKR was difficult, whilst a VMAR afforded a product with the opposite stereochemistry at the C20 position on the side chain. These results led us to redesign our synthetic strategy for the total synthesis of compound1.