Comparison of changes in lipid profile after bilio-intestinal bypass and gastric banding in patients with morbid obesity
Comparison of changes in lipid profile after bilio-intestinal bypass and gastric banding in patients with morbid obesity
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DOI：
10.1381/0960892053576839
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发表时间：
2005-03-01
期刊：
影响因子：
2.9
通讯作者：
Badiali, M
中科院分区：
文献类型：
--
作者：
Corradini, SG;Eramo, A;Badiali, M
背景资料：高胆固醇血症的存在是目前不被认为是一个选择标准进行胃限制性或改道减肥surgery.Methods：我们前瞻性地调查了胆肠旁路（BI-旁路）与广泛的胆囊空肠吻合和可调胃束带（AGB）对肥胖患者的血脂浓度的影响。为了阐明Bl-旁路的降胆固醇作用的机制，通过气液色谱法（GLC）测量每日粪便固醇排泄。与基线相比，在BI旁路术后1年，高胆固醇血症（n=18）和正常胆固醇血症（n=19）患者的总胆固醇水平显著降低，（分别为-38%和-27%）、LDL（分别为47%和-24%）和HDL（分别为-11%和-13%）胆固醇和总/HDL胆固醇比率（分别为-25%和-13%）。在AGB后1年，与基线相比，高胆固醇血症患者（n=12）的总/ HDL胆固醇比值显著降低（-11%），但胆固醇正常患者（n=6）的总胆固醇和LDL胆固醇均未受到影响。与基线相比，在Bl旁路术后3年，高胆固醇血症（n=9）和正常胆固醇血症（n=11）患者显著降低了总胆固醇（分别为-43%和-28%）和LDL（分别为-53%和-29%）以及总/ HDL胆固醇比率（分别为-38%和-21%）。体外循环组与对照组相比，
Background: The presence of hypercholesterolemia is currently not considered a selection criteria for performing gastric restrictive or diversionary bariatric surgery.Methods: We prospectively investigated the effects of the billo-intestinal bypass (BI-bypass) with a wide cholecysto-jejunal anastomosis and of adjustable gastric banding (AGB) on blood lipid concentrations in obese patients. To clarify the mechanism of the hypocholesterolemic effect of the Bl-bypass, daily fecal sterol excretion was measured by gas-liquid chromatography (GLC).Results: At 1 year after Bl-bypass compared to baseline, the hypercholesterolemic (n=18) and the normocholesterolemic (n=19) patients significantly reduced total (-38% and -27%, respectively), LDL (47% and -24%, respectively) and HDL (-11% and -13%, respectively) cholesterol and total /HDL cholesterol ratio (-25% and -13%, respectively). At 1 year after AGB, the total / HDL cholesterol ratio was significantly decreased (-11%) compared to baseline in hypercholesterolemic (n=12) but not in normocholesterolemic (n=6) patients, while total and LDL cholesterol were not affected in both groups. At 3 years after Bl-bypass compared to baseline, the hypercholesterolemic (n=9) and the normocholesterolemic (n=11) patients significantly reduced total (-43% and -28%, respectively) and LDL (-53% and -29%, respectively) cholesterol and total / HDL cholesterol ratio (-38% and -21%, respectively). The BI-bypass induced a significant (P