Functional heterogeneity in the memory B-cell response.
Functional heterogeneity in the memory B-cell response.
复制标题
记忆 B 细胞反应中的功能异质性。
DOI：
10.1016/j.coi.2022.102281
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发表时间：
2023
影响因子：
7
通讯作者：
Laidlaw,BrianJ
中科院分区：
文献类型：
--
作者：
Henry,Brittany;Laidlaw,BrianJ
大多数疫苗会诱导强大的抗体和记忆 B 细胞 (MBC) 反应，从而能够介导保护性免疫。然而，疫苗接种后抗体滴度下降，需要注射加强疫苗以维持保护性抗体滴度。 MBC 在疫苗接种后稳定维持，并且可以快速产生抗体分泌细胞或在再次遇到抗原时经历进一步的亲和力成熟。反复遇到抗原会导致 MBC 的形成，这些 MBC 编码的抗体能够介导针对 SARS-CoV-2 和流感等病毒的广泛保护性免疫。在这里，我们总结了新的证据，表明 MBC 是由转录和表型不同的亚群组成的异质群体，这些亚群在抗原再次遇到时介导保护性免疫方面具有不同的作用，并研究了这些发现对开发能够引发广泛保护性免疫的疫苗的影响。
Most vaccines induce robust antibody and memory B-cell (MBC) responses that are capable of mediating protective immunity. However, antibody titers wane following vaccination necessitating the administration of booster vaccines to maintain a protective antibody titer. MBCs are stably maintained following vaccination and can rapidly give rise to antibody-secreting cells or undergo further affinity maturation upon antigen re-encounter. Repeated antigen encounter results in the development of MBCs that encode antibodies capable of mediating broadly protective immunity against viruses such as SARS-CoV-2 and influenza. Here, we summarize emerging evidence that MBCs are a heterogeneous population composed of transcriptionally and phenotypically distinct subsets that have discrete roles in mediating protective immunity upon antigen re-encounter and examine the implications of these findings for the development of vaccines capable of eliciting broadly protective immunity.