Glucose tolerance in pregnancy in South India: relationships to neonatal anthropometry
Glucose tolerance in pregnancy in South India: relationships to neonatal anthropometry
复制标题
DOI：
10.1111/j.0001-6349.2005.00670.x
复制
发表时间：
2005-02-01
影响因子：
4.3
通讯作者：
Fall, CHD
中科院分区：
文献类型：
--
作者：
Hill, JC;Krishnaveni, GV;Fall, CHD
背景。2型糖尿病的发病率正在全球范围内增加，在印度等发展中国家增长最快。胎儿暴露于母体妊娠期糖尿病被认为是患此病的一个危险因素。本研究旨在确定印度南部一个城市产科的妊娠期糖尿病发病率，并研究其对后代新生儿人体测量、儿童生长和葡萄糖/胰岛素代谢的影响。本文报道新生儿预后。从迈索尔霍尔兹沃斯纪念医院产前门诊连续招募785名妇女，在妊娠30 +/- 2周时进行100 g， 3小时口服葡萄糖耐量试验。采用Carpenter和Coustan标准定义妊娠期糖尿病。这些婴儿在出生时被详细测量。产妇平均年龄23.6岁，体重指数23.1 kg/m(2)。妊娠期糖尿病的发生率为6.2%。患有妊娠期糖尿病的母亲生下的婴儿体重更重（3339克，而非糖尿病母亲的婴儿体重为2956克），脂肪、肌肉和骨骼的测量值也更大。即使在非糖尿病妊娠中，新生儿体重、头围和ponderal指数与母体空腹血糖浓度呈正相关（P均小于或等于0.05）。妊娠糖尿病的发病率是高的，在这个未选择的母亲样本预订到一个印度城市产科单位。需要以社区为基础的研究来证实这一点。母体葡萄糖浓度对新生儿人体测量的影响是持续的，并延伸到“正常”血糖范围。
Background. The incidence of type 2 diabetes is increasing worldwide, most rapidly in developing countries such as India. Exposure as a fetus to maternal gestational diabetes is thought to be a risk factor for developing the disease. This study was set up to determine the incidence of gestational diabetes mellitus in one urban maternity unit in South India and to examine its effect on the offspring's neonatal anthropometry, childhood growth, and glucose/insulin metabolism. This paper reports neonatal outcomes.Methods. Seven hundred and eighty five women were recruited consecutively from the antenatal clinic of the Holdsworth Memorial Hospital, Mysore and underwent a 100 g, 3-hr oral glucose tolerance test at 30 +/- 2 weeks gestation. Gestational diabetes was defined using Carpenter and Coustan criteria. The babies were measured in detail at birth.Results. Mean maternal age and body mass index were 23.6 years and 23.1 kg/m(2). The incidence of gestational diabetes was 6.2%. Mothers with gestational diabetes had babies that were heavier (3339 g compared with 2956 g for non-diabetic mothers) and larger in measurements of fat, muscle, and skeleton. Even in non-diabetic pregnancies, neonatal weight, head circumference, and ponderal index were positively related to maternal fasting glucose concentrations (P less than or equal to 0.05 for all).Conclusions. The incidence of gestational diabetes was high in this unselected sample of mothers booking into one urban Indian maternity unit. Community-based studies are required to confirm this. The effect of maternal glucose concentrations on neonatal anthropometry is continuous and extends into the 'normal' glycemic range.