Association of homocysteine levels with blood lead levels and micronutrients in the US general population.
Association of homocysteine levels with blood lead levels and micronutrients in the US general population.
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DOI：
10.3961/jpmph.2012.45.6.387
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Lee DH
中科院分区：
文献类型：
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作者：
Lee YM;Lee MK;Bae SG;Lee SH;Kim SY;Lee DH
尽管一些流行病学研究已经观察到血铅水平和同型半胱氨酸之间的正相关性，但没有研究检查这种关联是否与微量营养素水平不同，如叶酸，维生素B6和维生素B12，这些都参与了同型半胱氨酸的代谢。在这项研究中，我们研究了微量营养素和血铅之间的相互作用对同型半胱氨酸水平。本研究使用2003-2004年国家健康和营养检查调查，在美国普通人群中对4089名≥20岁的成人进行了研究。微量营养素和血铅水平对平均同型半胱氨酸水平有显著或轻微的相互作用。在叶酸水平低或维生素B6水平低的受试者中，明显观察到血铅和同型半胱氨酸之间的正相关性（分别为p趋势<0.01）。然而，在维生素B12的情况下，与维生素B12水平低的受试者相比，维生素B12水平高的受试者血铅和同型半胱氨酸之间存在更强的正相关性。事实上，无论血铅水平如何，维生素B12水平低的受试者的同型半胱氨酸水平已经很高。当我们使用高同型半胱氨酸血症（同型半胱氨酸>15 μmol/L）作为结果时，存在类似的相互作用模式，尽管每种相互作用的p值未能达到统计学显著性。在目前的研究中，血铅和同型半胱氨酸之间的关联根据血液中叶酸，维生素B6或维生素B12的水平而有所不同。保持足够的微量营养素水平可能是重要的，以防止铅暴露对同型半胱氨酸水平可能产生的有害影响。
Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels. This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004. There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance. In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.