Erythropoietin production in the fetal lamb.
Erythropoietin production in the fetal lamb.
复制标题
胎羔中促红细胞生成素的产生。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
D. L. Hutchinson
中科院分区：
文献类型：
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作者：
E. Zanjani;E. O. Horger;A. S. Gordon;L. Cantor;D. L. Hutchinson
摘要5只胎羊（妊娠95 ~ 123天）经颈静脉直接慢性注射苯肼。促红细胞生成素（ESF）出现在这些胎儿的血浆中，ESF的存在量与苯肼引起的贫血的强度直接相关。在母体血浆中任何时间均未发现ESF。胎儿血浆中ESF水平的波动是反应的特征，可能是由于血浆基质量的变化所致，肾促红细胞生成因子（REF）在血浆基质上产生ESF。这项研究的结果确定了哺乳动物胎儿产生ESF的能力，以应对一种形式的缺氧。
Abstract Five fetal lambs (day 95 to 123 of gestation) received chronic injections of phenylhydrazine by direct introduction into their jugular veins. Erythropoietin (ESF) appeared in the plasma of these fetuses, and the quantities of ESF present were directly related to the intensity of anemia induced by the phenylhydrazine. No ESF was demonstrable at any time in the maternal plasma. Fluctuations in the levels of ESF in fetal plasma, which were characteristic of the response, may be due to variations in the quantities of plasma substrate upon which the renal erythropoietic factor (REF) operates to produce the ESF. The results of this study establish with certainty the ability of a mammalian fetus to produce the ESF in response to a form of hypoxia.