The lifetime occurrence of Herpes zoster and prevalence of post-herpetic neuralgia: A retrospective survey in an elderly population
The lifetime occurrence of Herpes zoster and prevalence of post-herpetic neuralgia: A retrospective survey in an elderly population
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DOI：
10.1016/s1090-3801(99)90015-0
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发表时间：
1999-01-01
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影响因子：
--
通讯作者：
Bowsher, D
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文献类型：
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作者：
Bowsher, D
从人类衰老研究所（利物浦大学精神病学系）招募了1，071名随机选择的老年人（537名女性，534名男性;中位年龄80岁）。近四分之一（23.8%;男女人数相等）在中位年龄60岁（男女）时患有带状疱疹（HZ）; 39名受试者（占所有受访者的3.6%，占带状疱疹患者的15%），其中三分之二为女性，发生疱疹后神经痛（PHN），定义为疼痛持续3个月以上;他们在中位年龄70岁时获得HZ。其中22人的疼痛在接受询问时已经消退，但17人的疼痛仍在持续（从不到12个月到504个月）。PHN的两个新的独立危险因素被确定：（1）女性;（2）在HZ获得时独自生活（p = 0.009）。除了确认众所周知的因素：（3）带状疱疹收购的年龄（到90年代初）;（4）疤痕，推测是皮疹严重程度的后果，是显着常见的科目，HZ其次是PHN.Extrapolating的患病率数字，整个英国人口，其中928万人在1992年超过64。据保守估计，在任何时候，英国约有20万人患有PHN。(C)1999年国际疼痛研究协会欧洲分会联合会。
One-thousand-and-seventy-one randomly chosen elderly persons (537 women, 534 men; median age 80) were recruited from the Institute of Human Aging (Dept of Psychiatry, University of Liverpool). Almost a quarter (23.8%; equal numbers of both sexes) had had shingles (HZ), at a median age of 60 (for both sexes); 39 subjects (3.6% of all respondents, 15% of those who had had shingles), two thirds of whom were female, developed post-herpetic neuralgia (PHN), defined as pain persisting for more than 3 months; they acquired HZ at a median age of 70. In 22 of them, pain had resolved by the time they were questioned, but in 17 it was ongoing (from less than 12 to 504 months). Two new independent risk factors for PHN were identified: (1) female gender; and (2) living alone at the time of HZ acquisition (p = 0.009). In addition to confirming the well-known factor of: (3) age at shingles acquisition (up to the early 90s); and (4) scarring, presumed to be a consequence of rash severity, was significantly commoner in subjects whose HZ was followed by PHN.Extrapolating the prevalence figures to the whole UK population, of whom 9.28 million were over 64 in 1992. it can be conservatively estimated that at any one time, some 200 000 people in the UK have PHN. (C) 1999 European Federation of Chapters of the International Association for the Study of Pain.