Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.
Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.
复制标题
DOI：
10.1016/j.stem.2019.04.010
复制
发表时间：
2019-05
期刊：
影响因子：
23.9
通讯作者：
Christopher W. Peterson;H. Kiem
中科院分区：
文献类型：
--
作者：
Christopher W. Peterson;H. Kiem
最近，Gupta等人（2019）在nature杂志上报道，第二名患者在携带CCR5辅助受体突变的供体的异体造血干细胞移植后实现了HIV-1缓解/功能治愈。我们重点介绍了两种患者的治疗方法，并总结了开发更广泛、更有利于患者的方法的努力。
Recently inNature, Gupta et al. (2019) reported that a second patient has achieved HIV-1 remission/functional cure after allogeneic hematopoietic stem cell transplantation from a donor carrying a mutation in the CCR5 coreceptor. We highlight both patients' treatments and summarize efforts to develop a broader, more patient-friendly approach.