Potassium ion currents in the crayfish giant axon. Dynamic characteristics.
Potassium ion currents in the crayfish giant axon. Dynamic characteristics.
复制标题
小龙虾巨轴突中的钾离子电流。
DOI：
10.1016/s0006-3495(81)84761-3
复制
发表时间：
1981
影响因子：
3.4
通讯作者：
Moore,JW
中科院分区：
文献类型：
--
作者：
Young,SH;Moore,JW
The kinetics of the voltage-sensitive potassium channel in crayfish axon have been examined. The conductance increase after a step depolarization from rest can be described by a first-order kinetic process raised to the third power. When conditioning voltage levels preceded the test pulse, the steady-state conductance was found to be independent of initial conditions. Depolarizing conditioning voltages in general allowed superposition of test voltage potassium currents by a shift along the time axis. Hyperpolarizing conditioning voltages produced a delay in onset of conductance during the test pulse and changed the kinetics so that superposition was not possible. The delay increased during the hyperpolarization with a first-order lag having a time constant in the range of 1.5–3 ms. Return to the resting level caused recovery from the delayed state to follow a single exponential decay with a time constant of 1.9–2.2 ms. The steady state delay vs. voltage curves were not saturated at potentials as negative as -180 mV.
