Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys
Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys
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DOI：
10.1152/jn.00968.2003
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发表时间：
2004-05-01
影响因子：
2.5
通讯作者：
Murray, EA
中科院分区：
文献类型：
--
作者：
Izquierdo, A;Murray, EA
杏仁核和眶前额叶皮层（PFo）作为情感处理系统的一部分相互作用。为了评估是否有一个半球的功能专业化的处理情绪或奖励或两者兼而有之，在非人类灵长类动物，恒河猴（猕猴）与杏仁核和PFO在一个半球，无论是左或右，合并病变进行了比较，与未操作的控制电池的任务，税收情感处理，包括两个任务，税收奖励处理和两个评估情绪反应。虽然两个手术组没有彼此不同，单侧病变的猴子，左，右，表现出改变奖励处理能力的减弱的货币贬值效应和减值的对象反转学习相对于对照组。此外，两个手术组都表现出对橡胶蛇的迟钝情绪反应。相比之下，单侧病变的猴子在对陌生人（人类“入侵者”）的反应方面与对照组没有差异。虽然研究结果没有提供支持的半球专业化的功能，他们产生的新发现，单侧病变的杏仁核眶额皮质回路的猴子足以显着破坏情感处理。
The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys (Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human "intruder"). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.