INHIBITION BY CHLOROPHYLLIN OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE-INDUCED TUMORIGENESIS IN THE MALE F344 RAT
INHIBITION BY CHLOROPHYLLIN OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE-INDUCED TUMORIGENESIS IN THE MALE F344 RAT
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DOI：
10.1016/0304-3835(95)03882-w
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发表时间：
1995-08-16
期刊：
影响因子：
9.7
通讯作者：
DASHWOOD, RH
中科院分区：
文献类型：
--
作者：
GUO, DX;HORIO, DT;DASHWOOD, RH
本报告描述了一项为期1年的致癌性生物测定，在研究的前35周，雄性F344大鼠每周灌胃2-3次2-氨基-3-甲基咪唑[4,5-f]喹啉（IQ），同时在饮用水中同时给予0.1%的叶绿素钠/铜（CHL）。计算出的致癌物剂量为每只老鼠每天平均暴露在4.2毫克智商的环境中，相当于之前一项致癌性研究中报告的水平，该研究中，老鼠的饮食中智商为0.03%。经随访时间调整后，对总肿瘤负荷的抑制非常显著（P < 0.001），对小肠和淋巴腺的特定部位的抑制显著（P小于或等于0.1），对肝脏的抑制显著（P < 0.01）。给予CHL的大鼠，淋巴腺肿瘤的首次发病时间从第20周延迟至第36周，皮肤肿瘤的首次发病时间从第31周缩短至第26周（P < 0.05）。这些结果支持CHL在大鼠IQ肿瘤发生的几个主要靶器官中的化学预防作用，但引起了对皮肤可能有害影响的关注。
This report describes a 1-year carcinogenicity bioassay in which male F344 rats received 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by gavage 2-3 times per week throughout the first 35 weeks of study, while 0.1% sodium/copper chlorophyllin (CHL) was given concomitantly in the drinking water. The carcinogen dose was calculated to provide an average exposure of 4.2 mg IQ/rat per day, equivalent to that reported in a previous carcinogenicity study in which rats were given 0.03% IQ in the diet. Adjusted for length of follow-up, inhibition was highly significant for total tumor burden (P < 0.001), and for specific sites was significant in the small intestine and Zymbal's gland (P less than or equal to 0.1), and in the liver (P < 0.01). In rats given CHL, the first onset of tumors in the Zymbal's gland was delayed from week 20 to 36, but was shortened from week 31 to 26 in the skin (P < 0.05). These results support a chemopreventive role for CHL in several of the major target organs for IQ tumorigenesis in the rat, but raise concerns over possible deleterious effects in the skin .