Timing of corticosteroid treatment. Effect of lung lymph dynamics in air injury in awake sheep.
Timing of corticosteroid treatment. Effect of lung lymph dynamics in air injury in awake sheep.
复制标题
皮质类固醇治疗的时机。
DOI：
10.1164/ajrccm/142.4.872
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Staub,NC
中科院分区：
文献类型：
--
作者：
Jerome,EH;Bonsignore,MR;Albertine,KH;Culver,PL;Dodek,PD;Perel,A;Staub,NC
在配对实验中，我们研究了大剂量甲基强的松龙对19只患有肺淋巴瘘的慢性器械化、未麻醉绵羊静脉空气栓塞4 h引起的急性肺损伤的影响。我们比较了栓塞前、栓塞过程早期（1小时）、栓塞过程晚期（3小时）或栓塞后（恢复期开始时）给予甲基强的松龙（30 mg/kg静脉推注）的效果。
In paired experiments, we studied the effects of high-dose methylprednisolone on the acute pulmonary injury caused by 4 h of venous air embolization in 19chronically instrumented, unanesthetized sheep with lung lymph fistulas. Wecompared the effect of methylprednisolone (30 mg/kg intravenous bolus) given before embolization, early (1 h) in the course of embolization, late (3 h) in the course of embolization, or after embolization (at the beginning of the recovery period).