mTOR Regulation of Lymphoid Cells in Immunity to Pathogens.
mTOR Regulation of Lymphoid Cells in Immunity to Pathogens.
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DOI：
10.3389/fimmu.2016.00180
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发表时间：
2016
影响因子：
7.3
通讯作者：
McGargill MA
中科院分区：
文献类型：
--
作者：
Keating R;McGargill MA
对病原体的免疫性作为促进效应细胞的活化和扩增之间的精细平衡而存在，同时限制正常和异常应答。这些看似对立的功能被免疫调节器控制着。雷帕霉素（mTOR）的机制靶点是丝氨酸/苏氨酸激酶，其感知营养物质的可用性，进而相应地调节细胞代谢、生长和存活。mTOR通过调节淋巴样细胞的分化、活化和效应子功能，在促进针对入侵病原体的免疫防御中发挥关键作用。在这里，我们专注于新兴的，有时是矛盾的mTOR在协调淋巴细胞介导的宿主免疫反应的病原体的作用。深入了解mTOR如何影响淋巴细胞在病原体防御中的作用，将为开发感染性疾病的治疗干预措施提供必要的基础。
Immunity to pathogens exists as a fine balance between promoting activation and expansion of effector cells, while simultaneously limiting normal and aberrant responses. These seemingly opposing functions are kept in check by immune regulators. The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that senses nutrient availability and, in turn, regulates cell metabolism, growth, and survival accordingly. mTOR plays a pivotal role in facilitating immune defense against invading pathogens by regulating the differentiation, activation, and effector functions of lymphoid cells. Here, we focus on the emerging and sometimes contradictory roles of mTOR in orchestrating lymphoid cell-mediated host immune responses to pathogens. A thorough understanding of how mTOR impacts lymphoid cells in pathogen defense will provide the necessary base for developing therapeutic interventions for infectious diseases.