Hypoxia alters blood coagulation during acute decompression in humans.
Hypoxia alters blood coagulation during acute decompression in humans.
复制标题
缺氧会在人类急性减压过程中改变血液凝固。
DOI：
10.1152/jappl.1984.56.3.666
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Coates
中科院分区：
文献类型：
--
作者：
H. O'brodovich;M. Andrew;G. Gray;G. Coates
急性减压与活化部分凝血活酶时间（aPTT）缩短有关。本研究旨在检查aPTT的这种变化是否由缺氧或低气压引起。我们将健康成人在三个不同的场合暴露于2小时的1）缺氧低气压（410托，n = 5），2）缺氧正常气压（分数吸入O2张力= 0.11，n = 4），或3）常氧低气压（410托呼吸补充O2，n = 5）。aPTT在低氧和常氧时均缩短（P <0.05），而常氧时无变化。凝血酶原时间和凝血酶时间、红细胞压积、纤维蛋白原浓度、总血浆蛋白和纤维蛋白原-纤维蛋白片段E均无变化。在低氧hypobaria生物水平的前激肽释放酶，高分子量激肽原，因子XII，XI，X，VII，V和II不变，但促凝血VIII（VIII：C）增加50%，而没有增加VIII相关抗原水平（VIIIR：Ag）。任何组均未检测到纤维蛋白单体。在一名受试者中，在缺氧正常环境1.5小时后患病，aPTT缩短了10 s;血小板计数减少了93，000/mm 3; VIII：C增加了5倍，但VIIIR：Ag仅增加了3倍。我们的结论是，这是缺氧，缩短aPTT急性减压至410托，并推测，这是从血浆VIII：C样活性增加的结果。
Acute decompression is associated with a shortening of the activated partial thromboplastin time (aPTT). This study was performed to examine whether this change in aPTT results from hypoxia or hypobaria. We exposed healthy adults on three separate occasions to 2 h of 1) hypoxic hypobaria (410 Torr, n = 5), 2) hypoxic normobaria (fractional inspired O2 tension = 0.11, n = 4), or 3) normoxic hypobaria (410 Torr breathing supplemental O2, n = 5). The aPTT shortened during hypoxic hypobaria and hypoxic normobaria (P less than 0.05) but was unchanged during normoxic hypobaria. The prothrombin and thrombin times, hematocrit, and concentrations of fibrinogen, total plasma protein, and fibrinogen-fibrin fragment E were unchanged. During hypoxic hypobaria biologic levels of prekallikrein, high-molecular-weight kininogen, and factors XII, XI, X, VII, V, and II were unchanged, but procoagulant VIII (VIII:C) increased 50% without an increase in VIII-related antigen levels (VIIIR:Ag). Fibrin monomer was not detected in any group. In one subject who became ill after 1.5 h of hypoxic normobaria aPTT shortened by 10 s; the platelet count decreased by 93,000/mm3; VIII:C increased fivefold, but VIIIR:Ag only increased three-fold. We conclude that it is the hypoxia which shortens aPTT during acute decompression to 410 Torr and speculate that it results from an increase in plasma VIII:C-like activity.