THE RAC AND RHO PATHWAYS AS A SOURCE OF DRUG TARGETS FOR RAS-MEDIATED MALIGNANCIES
THE RAC AND RHO PATHWAYS AS A SOURCE OF DRUG TARGETS FOR RAS-MEDIATED MALIGNANCIES
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DOI：
10.1016/0958-1669(95)80110-3
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发表时间：
1995-12-01
影响因子：
7.7
通讯作者：
SYMONS, M
中科院分区：
文献类型：
--
作者：
SYMONS, M
小 GTP 结合蛋白 Rac 和 Rho 是生长因子或致癌 Ras 诱导的肌动蛋白细胞骨架重组的关键控制元件。最近确定 Rac 和 Rho 在 Ras 转化中也发挥着至关重要的作用。这表明 Rac 和 Rho 调节途径中的元件是癌症治疗的有效药物靶点。这些信号通路的几个重要组成部分现已被确定。
The small GTP-binding proteins Rac and Rho are key control elements in the reorganization of the actin cytoskeleton induced by growth factors or oncogenic Ras. It has been established recently that Rac and Rho also play a crucial role in Ras transformation. This suggests that the elements in the pathways regulated by Rac and Rho are valid drug targets for cancer therapy. Several important components of these signaling pathways have now been identified.