A model of prefrontal cortical mechanisms for goal-directed behavior
A model of prefrontal cortical mechanisms for goal-directed behavior
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DOI：
10.1162/0898929054475190
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发表时间：
2005-07-01
影响因子：
3.2
通讯作者：
Hasselmo, ME
中科院分区：
文献类型：
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作者：
Hasselmo, ME
许多行为任务需要目标导向的行动来获得延迟奖励。前额叶皮层似乎介导了目标导向决策的许多方面。这篇文章提出了一个强调目标相关活动对选择下一个运动输出的影响的前额叶皮质功能模型。该模型可以用强化学习理论的关键要素来解释。不同的新皮层小柱代表不同的感觉输入状态和不同的运动输出动作。每个小列的动态包括编码和检索的单独阶段。在编码过程中，兴奋性连接的加强在每个状态、后续动作和后续状态（可能包括奖励）之间形成正向和反向关联。在检索过程中，活动从奖励状态扩散到整个网络。这种传播活动与特定输入状态的交互指导下一个适当动作的选择。模拟实验证明了这些机制如何在一系列目标导向任务中指导表现，并为先前在大鼠空间记忆任务中观察到的内侧前额叶皮层中的一些神经元反应提供了功能框架。
Many behavioral tasks require goal-directed actions to obtain delayed reward. The prefrontal cortex appears to mediate many aspects of goal-directed decision making. This article presents a model of prefrontal cortex function emphasizing the influence of goal-related activity on the choice of the next motor output. The model can be interpreted in terms of key elements of Reinforcement Learning Theory. Different neocortical minicolumns represent distinct sensory input states and distinct motor output actions. The dynamics of each minicolumn include separate phases of encoding and retrieval. During encoding, strengthening of excitatory connections forms forward and reverse associations between each state, the following action, and a subsequent state, which may include reward. During retrieval, activity spreads from reward states throughout the network. The interaction of this spreading activity with a specific input state directs selection of the next appropriate action. Simulations demonstrate how these mechanisms can guide performance in a range of goal-directed tasks, and provide a functional framework for some of the neuronal responses previously observed in the medial prefrontal cortex during performance of spatial memory tasks in rats.