Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes.
Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes.
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DOI：
10.1038/ncpcardio0444
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Hedrick, Marc H
中科院分区：
文献类型：
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作者：
Fraser, John K;Schreiber, Ronda;Hedrick, Marc H
最近的临床前和临床研究表明，成体干细胞具有促进急性和慢性缺血心脏功能保留或恢复的能力。已发表的临床研究使用了自体供体细胞，包括骨骼肌成肌细胞、培养的外周血细胞或骨髓细胞。然而，我们和其他人的研究表明，人类脂肪组织是具有心脏细胞治疗潜力的细胞的替代来源。这些发现包括脂肪组织中存在细胞，这些细胞可以分化成表达心肌细胞或内皮细胞表型的细胞，以及血管生成和抗凋亡生长因子。这一潜力得到了大型动物临床前研究的支持。
Recent preclinical and clinical studies have suggested that adult stem cells have the ability to promote the retention or restoration of cardiac function in acute and chronic ischemia. Published clinical studies have used autologous donor cells, including skeletal muscle myoblasts, cultured peripheral blood cells, or bone marrow cells. However, our research and that of others indicates that human adipose tissue is an alternative source of cells with potential for cardiac cell therapy. These findings include the presence of cells within adipose tissue that can differentiate into cells expressing a cardiomyocytic or endothelial phenotype, as well as angiogenic and antiapoptotic growth factors. This potential is supported by preclinical studies in large animals.