HUMAN-MILK FEEDING ENHANCES THE URINARY-EXCRETION OF IMMUNOLOGICAL FACTORS IN LOW BIRTH-WEIGHT INFANTS
HUMAN-MILK FEEDING ENHANCES THE URINARY-EXCRETION OF IMMUNOLOGICAL FACTORS IN LOW BIRTH-WEIGHT INFANTS
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DOI：
10.1203/00006450-198902000-00021
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发表时间：
1989-02-01
影响因子：
3.6
通讯作者：
GOLDMAN, AS
中科院分区：
文献类型：
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作者：
GOLDBLUM, RM;SCHANLER, RJ;GOLDMAN, AS
在极低出生体重婴儿中研究了强化母乳喂养对乳铁蛋白、溶菌酶、分泌成分、IgA 和大肠杆菌 O 抗原分泌型 IgA 抗体尿排泄的影响。婴儿以母乳或牛奶制剂维持。在 2.5 周和 5 周龄时进行的平衡研究中，对摄入和排泄的每种免疫因子的量进行了量化。两个喂养组中这些免疫因子的血清水平相似。除溶菌酶外，所有因子在尿中的排泄量，母乳喂养的婴儿比配方奶粉喂养的婴儿高 7 至 150 倍。 IgA 是唯一一个其排泄量与摄入量相关的因子。在母乳喂养的婴儿的尿液中发现了乳铁蛋白的片段和完整分子，但排出的蛋白质的分子大小超过了肾脏正常过滤的蛋白质的分子大小。因此，母乳喂养的婴儿尿液中宿主防御因子水平升高的原因尚不清楚。胃肠道吸收和随后的肾脏排泄以及婴儿泌尿道中免疫因子的产生增强是可能的解释。
The effects of fortified human milk feedings on the urinary excretion of lactoferrin, lysozyme, secretory component, IgA, and secretory IgA antibodies to Escherichia coli O antigens were investigated in very low birth wt infants. Infants were maintained on either a human milk or a cow''s milk preparation. The amounts of each immune factor that were ingested and excreted were quantified during balance studies conducted at 2.5 and 5 wk of age. Serum levels of these immune factors were similar in both feeding groups. The urinary excretion of all factors except lysozyme was 7- to 150-fold greater in infants fed human milk than in those fed cow''s milk formula. IgA was the only factor for which the amount of the factor excreted correlated with the amount ingested. Fragments as well as whole molecules of lactoferrin were found in the urine of the infants fed human milk, but the molecular sizes of the excreted proteins exceeded those normally filtered by the kidneys. Therefore, the genesis of the enhanced levels of host defense factors in the urine of infants fed human milk is not clear. Gastrointestinal absorption and subsequent renal excretion as well as enhance production of immune factors in the infant''s urinary tract are possible explanations.