Analysis of Mouse Growth Plate Development.
Analysis of Mouse Growth Plate Development.
复制标题
小鼠生长板发育分析。
DOI：
10.1002/9780470942390.mo150094
复制
发表时间：
2016
影响因子：
--
通讯作者：
Schipani,Ernestina
中科院分区：
文献类型：
--
作者：
Mangiavini,Laura;Merceron,Christophe;Schipani,Ernestina
To investigate skeletal development, pathophysiological mechanisms of cartilage and bone disease, and eventually assess innovative treatments, the mouse is a very important resource. During embryonic development, mesenchymal condensations are formed, and cells within these mesenchymal condensations either directly differentiate into osteoblasts and give origin to intramembranous bone, or differentiate into chondrocytes and form a cartilaginous anlage. The cartilaginous anlage or fetal growth plate is then replaced with bone. This process is also called endochondral bone development, and it is responsible for the generation of most of our skeleton. Here we discuss in detail the most common in vivo and in vitro techniques our laboratory is currently using for the analysis of the mouse fetal growth plate during development. © 2016 by John Wiley & Sons, Inc.
