Autonomic control of the diurnal variation in arterial blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats.
Autonomic control of the diurnal variation in arterial blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats.
复制标题
自发性高血压大鼠和 Wistar-Kyoto 大鼠动脉血压和心率昼夜变化的自主控制。
DOI：
10.1097/00004872-198910000-00005
复制
发表时间：
1989
影响因子：
4.9
通讯作者：
M. Nordlander
中科院分区：
文献类型：
--
作者：
P. Friberg;B. Karlsson;M. Nordlander
在自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）上，研究了交感神经和副交感神经对平均动脉压（MAP）和心率（HR）的相对影响及其变异性。一个在线的计算机系统用于连续动脉内测量MAP和HR在不受约束的大鼠。此外，还研究了自发性高血压大鼠（SHR）和正常对照大鼠（WKY）MAP和HR的自主神经调节。WKY和SHR的MAP和HR均表现出昼夜节律，SHR的MAP变异性在白天（不活动）和夜间（活动）均高于WKY，并且对β 1肾上腺素能受体或胆碱能受体阻滞没有反应。血管结构的变化，反应性的增加，可能解释了SHR的MAP变异性升高。HR变异性在SHR中明显降低;这不受迷走神经阻滞的影响，而HR变异性在WKY中显著降低。这种模式被认为是由于减少紧张性迷走神经放电在SHR，作为一个持久的，温和的防御反应的一部分。迷走神经活动的最初减少将反过来消除迷走神经介导的心动过速。此外，给不同年龄的SHR注射β 1-阻滞剂，MAP和HR的下降幅度大于WKY，表明SHR对交感神经系统的依赖性随着年龄的增长而增加。
The relative influences of sympathetic and parasympathetic neural modulation on mean arterial pressure (MAP) and heart rate (HR), and their respective variabilities, were studied in young spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). An on-line computerized system was used for continuous intra-arterial measurements of MAP and HR in unrestrained rats. In addition, the autonomic nervous control of MAP and HR was studied in ageing SHR and WKY. Both WKY and SHR showed diurnal rhythms with regard to MAP and HR. The MAP variability was higher in SHR than in WKY during both daytime (inactive) and night-time (active), and did not change in response to either beta 1-adrenoceptor- or cholinergic blockade. Structural vascular changes, with a resultant increase in reactivity, may explain the elevated MAP variability in SHR. HR variability was clearly reduced in SHR; this was not influenced by vagal blockade, whereas HR variability was significantly reduced in WKY. This pattern is suggested to be due to a reduced tonic vagal discharge in SHR, as part of a persistent, mild defence reaction. The initial reduction in vagal activity will in turn eliminate vagally mediated tachycardias. Furthermore, administration beta 1-blockade to SHR of different ages caused a greater fall in MAP and HR than in WKY, indicating an increased dependence upon the sympathetic nervous system in SHR with age.