Attenuated immune response to tetanus toxoid in young healthy men protected against tetanus
Attenuated immune response to tetanus toxoid in young healthy men protected against tetanus
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DOI：
10.1016/j.vaccine.2005.05.028
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发表时间：
2005-10-10
期刊：
影响因子：
5.5
通讯作者：
Sjursen, H
中科院分区：
文献类型：
--
作者：
Danilova, E;Shiryayev, A;Sjursen, H
破伤风加强剂是一种预防破伤风的常规程序，适用于受伤风险高的人群，与保护水平无关。但是已经受到保护的个体的免疫反应并没有得到很好的研究。我们通过间接ELISA法测量破伤风抗毒素水平来描述个体增强反应的动力学。在注射前、注射后1周、1月、2月、3月和6月对60名注射者进行了为期6个月的随访。初始保护作用高（平均滴度1.08 IU/ml）， 1个月后提高不到3倍。在抗毒素水平稳定1个月后，水平缓慢下降，6个月后平均滴度为1.78 IU/ml。与初始水平>= 1 IU/ml的个体相比，初始水平< 1 IU/ml的个体在第一个月后的增强反应高两倍。然而，在两组中，从1个月到6个月的下降幅度约为2倍。已经得到破伤风保护的个体对破伤风类毒素表现出一种减弱的、短时间的增强反应。这在注射前水平为>= 1 IU/ml的个体中更为明显，在注射后没有提高免疫保护。(c) 2005 Elsevier Ltd版权所有。
Tetanus booster is a routine procedure of tetanus prevention in populations with high risk of injury, independent of the levels of protection. But the immune response in already protected individuals is not well studied. We describe the kinetics of booster response in individuals by measuring tetanus antitoxin levels by indirect ELISA. A 6-month follow up was performed on 60 boosted individuals tested before, 1 week, 1, 2, 3 and 6 months after the booster. High initial protection (mean titer 1.08 IU/ml) and less than 3-fold increase after 1 month were observed. After I month of stable antitoxin levels, the levels slowly decreased and reached a mean titer of 1.78 IU/ml after 6 months. Individuals with initial levels < 1 IU/ml had booster response after the first month twice as high compared to those with initial level >= 1 IU/ml. However, in both groups, the decline from I to 6 months was about 2-fold. Individuals already protected against tetanus exhibited an attenuated, short-lasting booster response to tetanus toxoid. This was more pronounced in individuals with pre-booster levels >= 1 IU/ml, who did not improve immune protection after the booster. (c) 2005 Elsevier Ltd. All rights reserved.